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REVIEW article
Front. Endocrinol.
Sec. Cellular Endocrinology
Volume 16 - 2025 |
doi: 10.3389/fendo.2025.1541794
Autophagy-lysosome pathway in insulin & glucagon homeostasis
Provisionally accepted- 1 Zhoupu Hospital, Shanghai University of Medicine and Health Sciences, Shanghai, China
- 2 Shanghai University of Medicine and Health Sciences, Shanghai, China
Lysosome, a highly dynamic organelle, is an important nutrient sensing center. They utilize different ion channels and transporters to complete the mission in degradation, trafficking, nutrient sensing and integration of various metabolic pathways to maintain cellular homeostasis. Glucose homeostasis relies on tightly regulated insulin secretion by pancreatic β cells, and their dysfunction is a hallmark of type 2 diabetes. Glucagon also plays an important role in hyperglycemia in diabetic patients. Currently, lysosome has been recognized as a nutrient hub to regulate the homeostasis of insulin and other hormones. In this review, we will discuss recent advances in understanding lysosome-mediated autophagy and lysosomal proteins involved in maintaining insulin and glucagon homeostasis, as well as their contributions to the etiology of diabetes.
Keywords: Lysosome, Autophagy, Insulin homeostasis, Glucagon homeostasis, diabetes
Received: 08 Dec 2024; Accepted: 22 Jan 2025.
Copyright: © 2025 Wu, Wang and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yi Wu, Zhoupu Hospital, Shanghai University of Medicine and Health Sciences, Shanghai, China
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