REVIEW article
Front. Endocrinol.
Sec. Reproduction
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1541744
This article is part of the Research TopicLifestyle and Environmental Factors and Human FertilityView all 19 articles
Review of Mendelian Randomization Studies on Common Male-Specific Diseases
Provisionally accepted
- 1Henan University of Chinese Medicine, Zhengzhou, China
- 2School of Foreign Languages, Henan University of Chinese Medicine, Zhengzhou, Henan Province, China
- 3Queen Mary college, Nanchang University, Nanchang, Jiangxi Province, China
- 4Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou, Henan Province, China
- 5The Second Clinical Medical College, Henan University of Traditional Chinese Medicine, Zhengzhou, Henan Province, China
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Although numerous Mendelian randomization studies on risk factors have been conducted in male medicine, a systematic synthesis of these findings is still lacking. This review searched relevant literature in PubMed and the Web of Science published before May 2024; systematically summarized the progress in the application of Mendelian randomization in male infertility, erectile dysfunction, prostate cancer, and prostatitis; summarized and classified the risk factors affecting men's health, such as the gut microbiota, modifiable risk factors and related diseases; and presented some problems and solutions that were presented in these studies. This information offers valuable insights into the etiology and pathogenesis of male-specific diseases.
Keywords: Mendelian randomization1, male infertility2, Prostate cancer3, erectile dysfunction4, prostatitis5
Received: 08 Dec 2024; Accepted: 22 Apr 2025.
Copyright: © 2025 Pang, Chang, Liu, Chen, Zhang, Ma and Sun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Chenming Zhang, The Second Clinical Medical College, Henan University of Traditional Chinese Medicine, Zhengzhou, Henan Province, China
Sicheng Ma, The Second Clinical Medical College, Henan University of Traditional Chinese Medicine, Zhengzhou, Henan Province, China
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