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ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Systems Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1538603
This article is part of the Research Topic Insights in Host Genetics and Microbial Interaction of Gastrointestinal Diseases View all articles
Dissecting the bidirectional associations between the progression of gastrointestinal and endocrine diseases
Provisionally accepted- 1 Department of Endocrinology, Department of Endocrinology, Chinese PLA General Hospital, Beijing, China
- 2 Peking University Third Hospital, Haidian, Beijing Municipality, China
The widespread intrinsic link between gastrointestinal and endocrine diseases was poorly understood. We aimed to dissect the bidirectional association in the progression of gastrointestinal with endocrine diseases, either the overall, individual, or comorbidities with each other. overall endocrine (HR, 1.14; 95% CI, 1.12-1.16) and gastrointestinal diseases (HR, 1.50; 95% CI, 1.46-1.55) increased with per-comorbidity increasing. This trend was similarly observed for most individual diseases.We observed an extensive bidirectional association in overall, specific, and number of comorbidities between gastrointestinal and endocrine diseases.
Keywords: Gastrointestinal Diseases, Endocrine diseases, comorbidities, Bidirectional relationship, UK Biobank (UKB)
Received: 03 Dec 2024; Accepted: 10 Mar 2025.
Copyright: © 2025 Liu, Si, Zhang and Zhan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Siyan Zhan, Peking University Third Hospital, Haidian, 100191, Beijing Municipality, China
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