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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Bone Research
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1537574
This article is part of the Research Topic Bone Health and Development in Children and Adolescents: Volume II View all articles

Relationship Between Systemic Inflammatory Response Index and Bone Mineral Density in Children and Adolescents Aged 8-19 Years: A Cross-Sectional Study

Provisionally accepted
Dejun Cun Dejun Cun 1Nan Yang Nan Yang 1Lin Zhou Lin Zhou 1Wenxing Zeng Wenxing Zeng 1Bin Chen Bin Chen 2Zichen Pan Zichen Pan 3Huang Feng Huang Feng 4Ziwei Jiang Ziwei Jiang 4*
  • 1 The First Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China
  • 2 The First Clinical College of Yunnan University of Traditional Chinese Medicine, Kunming, Yunnan Province, China
  • 3 College of First Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China
  • 4 The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, China

The final, formatted version of the article will be published soon.

    Objective: This study aims to investigate the relationship between the Systemic Inflammatory Response Index (SIRI) and bone mineral density (BMD) in children and adolescents aged 8-19 years.A cross-sectional design was used, utilizing NHANES data from 2011-2016, including 3,205 participants aged 8 to 19 years. Weighted multivariable regression analysis was conducted to assess the association between SIRI and BMD at the lumbar spine, pelvis, trunk, and whole body. Additionally, smooth curve fitting was applied to examine the nonlinear relationship between SIRI and BMD, and subgroup analyses were performed to explore potential interaction effects and modifiers.Results: SIRI was significantly positively correlated with BMD at the pelvis, trunk, and whole body (p < 0.05). After adjusting for covariates, a one-unit increase in ln(SIRI) was associated with increases in BMD of 0.018 g/cm², 0.006 g/cm², and 0.005 g/cm² for the pelvis, trunk, and whole body, respectively. Nonlinear analysis revealed a saturation effect between ln(SIRI) and BMD, with a more pronounced impact at specific threshold values. Subgroup analysis indicated that gender, age, BMI and total calcium levels modulated the relationship between SIRI and BMD.SIRI is significantly associated with BMD in children and adolescents, with a positive effect on BMD at specific threshold levels. This finding suggests that SIRI may serve as a potential biomarker for assessing the risk of low bone mineral density, offering theoretical support for the prevention and intervention of bone health issues such as osteoporosis.

    Keywords: systemic inflammatory response index, bone mineral density, Children and adolescents, NHANES, Cross-sectional study

    Received: 01 Dec 2024; Accepted: 07 Feb 2025.

    Copyright: © 2025 Cun, Yang, Zhou, Zeng, Chen, Pan, Feng and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Ziwei Jiang, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, China

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