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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Clinical Diabetes
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1537303
This article is part of the Research Topic Highlights in Diabetes Nephropathy View all 7 articles

Association Between Atherogenic Index of Plasma and Type 2 Diabetic Complications: A Cross-Sectional Study

Provisionally accepted
Yue-Yang Zhang Yue-Yang Zhang Xiao-Yu Yang Xiao-Yu Yang Qin Wan Qin Wan *
  • Department of Endocrinology, The Affiliated Hospital of Southwest Medical University, Luzhou, China

The final, formatted version of the article will be published soon.

    BackgroundThe Atherogenic Index of Plasma (AIP) was originally developed primarily as a marker for assessing atherosclerosis. Consequently, this study investigates the potential association between AIP and type 2 diabetic complications through a cross-sectional design.MethodsThe National Metabolic Management Center(MMC) serves as a comprehensive platform dedicated to the establishment of standardized protocols for the diagnosis, treatment, and long-term follow-up of metabolic diseases. Following the relevant inclusion and exclusion criteria, a total of 3,094 patients were enrolled for subsequent analysis. In this study, logistic regression, restricted cubic splines, and subgroup analyses were employed to evaluate the association between the AIP and four major complications of type 2 diabetes, namely, type 2 diabetes with carotid atherosclerosis (DA), diabetic kidney disease (DKD), diabetic retinopathy (DR), and diabetic peripheral neuropathy (DPN).ResultsThe logistic regression results demonstrate that in the fully adjusted model, each SD increase in AIP correlates with an elevated risk of type 2 diabetic kidney disease (DKD), with the risk of kidney damage intensifying alongside higher AIP groupings. The RCS analysis and subgroup analyses similarly revealed a dose-response relationship between AIP levels and the risk of DKD. Furthermore, the AIP was not found to be statistically significantly associated with DA, DR,and DPN.ConclusionsThe AIP may serve as a valuable predictive indicator for evaluating kidney damage in patients with type 2 diabetes, and regular screening of AIP in this population could provide significant benefits in the prevention of DKD.

    Keywords: Atherogenic index of plasma, type 2 diabetes, diabetic complications, Metabolic Management Center, Cross-sectional study

    Received: 30 Nov 2024; Accepted: 14 Jan 2025.

    Copyright: © 2025 Zhang, Yang and Wan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Qin Wan, Department of Endocrinology, The Affiliated Hospital of Southwest Medical University, Luzhou, China

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