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ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Systems Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1536300
This article is part of the Research Topic Nutrition, Inflammation and Oxidative Stress in Obstetrics and Gynecology View all 12 articles
Exploring the link between serum uric acid and endometriosis: a crosssectional analysis utilizing NHANES data from 1999-2006
Provisionally accepted- Guangzhou Medical University, Guangzhou, China
Background: Substantial impacts on the female reproductive system have been definitively linked to heightened levels of serum uric acid. However, evidence directly linking increased serum uric acid levels to endometriosis in women remains sparse, and the precise characteristics of this influence are still not fully understood.Objective: To explore the exact relationship between serum uric acid and endometriosis.Referencing the data accumulated from the National Health and Nutrition Examination Survey (NHANES), this study covers the period from 1999 to 2006, conducted an analysis of 5,162 female participants aged 20 to 54 years (representing a sample size of approximately 66,927,890 women). The study adopted a cross-sectional methodology to delve into the tie between serum uric acid and the prevalence of endometriosis. Utilizing rigorous methodologies, including weighted multivariable logistic regression models、subgroup analyses, and statistical methodologies for smooth curve fitting.The study adopted a cross-sectional methodology to delve into the tie between serum uric acid and the prevalence of endometriosis. Utilizing rigorous methodologies, including weighted multivariable logistic regression models、subgroup analyses, and statistical methodologies for smooth curve fitting. The study indicates a strong link between increased serum uric acid levels and the appearance of endometriosis in women. Specifically, women with elevated uric acid levels face a higher likelihood of developing endometriosis.
Keywords: Endometriosis, Serum uric acid, Health Care, Risk factors, medical research
Received: 28 Nov 2024; Accepted: 26 Mar 2025.
Copyright: © 2025 Chen, Chen, Xiaotong, Tang, Liu, Shi and Ou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Wen-Jing Shi, Guangzhou Medical University, Guangzhou, China
Yu-Hua Ou, Guangzhou Medical University, Guangzhou, China
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