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ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Endocrinology of Aging
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1531325
This article is part of the Research Topic The Crosstalk Between Metabolism and Inflammation in Aging and Longevity View all 3 articles
NSAID Use May Decrease Serum Klotho Levels
Provisionally accepted- Eye and Ent Hospital, Fudan University, Shanghai, China
Objective To validate the hypothesis proposed by previous studies, which suggests that NSAID use may elevate Klotho levels.Method We conducted a cross-sectional study involving 11,626 adults from the National Health and Nutrition Examination Survey (NHANES) 2007-2016. Multivariable linear regression and propensity score analysis were employed to evaluate the association between NSAID use and serum Klotho levels. Additionally, subgroup analyses were performed to assess the consistency of this relationship across various subgroups.Results Multivariable linear regression analysis demonstrated that NSAID use was negatively correlated with serum Klotho levels (β = -25.48 [95% CI: -42.00, -8.96], p = 0.003). Additionally, sensitivity analysis results were consistent with the primary analysis. Subgroup analyses did not reveal any statistically significant interactions.Conclusion Contrary to previous speculations, the use of NSAIDs is associated with a decrease in serum Klotho levels.
Keywords: NSAIDs, cyclooxygenase, Inflammation, Aging, α-Klotho (Klotho)
Received: 21 Nov 2024; Accepted: 27 Mar 2025.
Copyright: © 2025 Yan, Sun, Xin and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Taomin Huang, Eye and Ent Hospital, Fudan University, Shanghai, China
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