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ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Reproduction
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1531221
This article is part of the Research TopicVascular Dysfunction and Endocrine DisordersView all 8 articles
Association between atherogenic index of plasma and testosterone deficiency in adults: evidence from NHANES 2011-2016
Provisionally accepted- 1Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences Tongji Shanxi Hospital, Taiyuan, 030032, China, Taiyuan, China
- 2Department of Urology, Shanxi Bethune Hospital, Shanxi Academy of Medical Science, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, 030032, China, Taiyuan, Shanxi Province, China
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AbstractBackgroundThe common pathophysiological association between lipid metabolism and sex hormone levels was revealed in recent researches. The atherogenic index of plasma (AIP) is the currently generated marker using to evaluate metabolism. Our purpose of the research was to discover the relevance between the levels of AIP and testosterone deficiency (TD) based on the nationwide representative population.MethodsBased on the National Health and Nutrition Examination Survey (NHANES) database, data from 2011 to 2016 were utilized in this cross-sectional research. The formulas, lg [TG (mmol/L)/HDL-C(mmol/L)], was applied to determine AIP. Total serum testosterone levels to define TD. Our researcher utilized smoothed curve fitting and multivariate logistic or liner regression analysis to inspect the relevance between AIP and TD among adult males. The consistency of these results was examined in various population subgroups.Results1198 individuals (28.6%) were stratified into the TD group. We observed statistically significant differences (P values < 0.05) in the TD population for all variables. After correcting for potential confounders, our researchers discovered the strong positive relevance between AIP and the probability of developing TD. With each additional unit of the AIP, the incidence of TD elevated by 2.81-fold in adult males. Subgroup analyses showed correlations for the majority of subgroups remained stable. However, marital status, CKD, smoking and alcohol consumption may modify this association.ConclusionsHigher AIP is linked with lower level of testosterone in adult males. This correlation may be altered by factors including marriage, chronic kidney disease, alcohol, smoking consumption.
Keywords: AIP, Testosterone deficiency, Lipid Metabolism, population-based studies, NHANES
Received: 20 Nov 2024; Accepted: 10 Apr 2025.
Copyright: © 2025 Tai, Chen, Kong and Shang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jiwen Shang, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences Tongji Shanxi Hospital, Taiyuan, 030032, China, Taiyuan, China
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