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REVIEW article
Front. Endocrinol.
Sec. Gut Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1526468
Metabolic disorders in polycystic ovary syndrome: from gut microbiota biodiversity to clinical intervention
Provisionally accepted
Jiyuan Li 1*
Jiashen Qiao 1* Yihan Li 1*
Gaofeng Qin 2
Yingjiang Xu 3 Kaixue Lao 4 Yanlin Wang 4 Yang Fan 5 Peiyi Tang 5
Lei Han 4*- 1 First Clinical College of Medicine, Binzhou Medical University, Binzhou, Shandong Province, China
- 2 Department of Traditional Chinese Medicine, Binzhou Medical University Hospital, Binzhou City, China
- 3 Department of Interventional Vascular Surgery, Binzhou Medical University Hospital, Binzhou City, China
- 4 Department of Reproductive Medicine, Binzhou Medical University Hospital , Binzhou City, Shandong Province , China, Binzhou City, Shandong Province, China
- 5 Department of Clinical Nutrition, Chongqing University Jiangjin Hospital, Chongqing, China
Polycystic ovary syndrome (PCOS) is a prevalent gynecologic endocrine disorder characterized by menstrual irregularities, elevated androgen levels, and ovulatory dysfunction. Its etiology is multifactorial. Emerging evidence indicates that PCOS patients exhibit diminished gut microbiota (GM) diversity and altered microbial ratios, contributing to the metabolic derangements observed in these individuals. This review elucidates the role of GM in the pathogenesis and metabolic disorders of PCOS, encompassing insulin resistance (IR), hormonal imbalances, bile acid metabolic disorders, Interleukin-22-mediated immune dysregulation, and brain-gut axis disturbances. Additionally, it synthesizes current therapeutic strategies targeting the GM, aiming to furnish a theoretical framework for prospective clinical interventions.
Keywords: Polycystic Ovary Syndrome, Gut Microbiota, metabolic disorders, Insulin Resistance, bile acids Background Polycystic ovary syndrome (PCOS) is a prevalent gynecological endocrine disorder
Received: 11 Nov 2024; Accepted: 31 Mar 2025.
Copyright: © 2025 Li, Qiao, Li, Qin, Xu, Lao, Wang, Fan, Tang and Han. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jiyuan Li, First Clinical College of Medicine, Binzhou Medical University, Binzhou, 256603, Shandong Province, China
Jiashen Qiao, First Clinical College of Medicine, Binzhou Medical University, Binzhou, 256603, Shandong Province, China
Yihan Li, First Clinical College of Medicine, Binzhou Medical University, Binzhou, 256603, Shandong Province, China
Lei Han, Department of Reproductive Medicine, Binzhou Medical University Hospital , Binzhou City, Shandong Province , China, Binzhou City, Shandong Province, China
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