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CASE REPORT article
Front. Endocrinol.
Sec. Neuroendocrine Science
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1524288
Case report: Radiofrequency ablation of insulinoma following diazoxide-induced diabetic ketoacidosis
Provisionally accepted- National University Health System (Singapore), Singapore, Singapore
Definitive management of insulinoma is challenging as curative surgery is associated with a considerable risk of morbidity and mortality. The successful long-term use of diazoxide for patients diagnosed with insulinoma has been described, but rarely, the use of diazoxide can be complicated by diabetic ketoacidosis (DKA). This case report describes a frail elderly patient with high surgical risk diagnosed with pancreatic head insulinoma whose initial treatment with diazoxide was complicated by hyperglycemic crisis. Her insulinoma was eventually managed with endoscopic ultrasound guidedradiofrequency ablation (EUS-RFA) with complete resolution of hypoglycemic episodes. This case highlights the importance of monitoring for side effects of diazoxide especially in the elderly and the role of EUS-RFA as an emerging non-surgical treatment modality for insulinoma.
Keywords: Insulinoma, Diazoxide, Diabetic Ketoacidosis, endoscopic ultrasound, Radiofrequency ablation
Received: 07 Nov 2024; Accepted: 04 Mar 2025.
Copyright: © 2025 Chin, Kiew, Ho and Deepak. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Run Ting Chin, National University Health System (Singapore), Singapore, Singapore
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