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ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Renal Endocrinology
Volume 16 - 2025 |
doi: 10.3389/fendo.2025.1523890
Association between the neutrophil-to-high-density lipoprotein cholesterol ratio with kidney stone risk: a cross-sectional study
Provisionally accepted- 1 Department of Urology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China
- 2 Department of Urology, Second Affiliated Hospital of University of South China, Hengyang, Hunan Province, China
Objective: Kidney stones are a major issue for public health worldwide. Discovering potential clues in identifying at-risk individuals is essential for early detection and timely treatment. This study explores the relationship of the neutrophil-to-high-density lipoprotein cholesterol ratio (NHR) with the risk of kidney stones in U.S. adults.The analysis involved 24,532 participants with available NHR and kidney stone data from the 2007-2018 NHANES period. Multivariable logistic regression models were used to quantify the relationship between NHR and kidney stone occurrence. Subgroup analyses were conducted to explore variations in effect.Results: A total of 2,351 participants (9.93%) were diagnosed with kidney stones, and their mean age was 47.20 ± 0.26 years. After full adjustment in the multivariable regression model, higher NHR levels were linked to a greater risk of kidney stones (OR = 1.05, 95% CI: 1.02-1.08, P = 0.002). Participants in the highest tertile of NHR had a 34% increased chance of kidney stone development compared to those in the lowest tertile. A nonlinear connection between NHR and kidney stone risk was identified using restricted cubic spline (RCS) regression models. The relationship between NHR and kidney stone prevalence showed no significant variation across most subgroups (P for interaction > 0.05).The results indicate that increased NHR is linked to a higher risk of kidney stones, with this relationship remaining consistent across various populations. NHR could be a useful biomarker for kidney stone risk, with key implications for early detection and individualized treatment.
Keywords: neutrophil-to-high-density lipoprotein cholesterol ratio, Kidney Stones, Neutrophil, High-density lipoprotein cholesterol, Cross-sectional study
Received: 11 Nov 2024; Accepted: 15 Jan 2025.
Copyright: © 2025 Du, Yang, Yao, Zhang and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Zhuo Yuan Du, Department of Urology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China
Qing Jia Yang, Department of Urology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China
Ming Ji Yao, Department of Urology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China
Teng Chi Zhang, Department of Urology, Second Affiliated Hospital of University of South China, Hengyang, Hunan Province, China
Fu Yi Liu, Department of Urology, Second Affiliated Hospital of University of South China, Hengyang, Hunan Province, China
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