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ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Neuroendocrine Science
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1521850
Associations between triglyceride-glucose indices and delirium risk in critically ill patients with acute kidney injury: a retrospective study
Provisionally accepted- School of Medicine, Anhui University of Science and Technology, Huainan, China
Background: Delirium frequently occurs in individuals with acute kidney injury (AKI), leading to serious adverse outcomes. However, there are currently no predictors of early intervention for delirium in clinical practice. This study aims to investigate whether a correlation exists between TyG indices and the clinical symptoms of delirium in patients with AKI.Methods: Eligible participants diagnosed with AKI from the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database were categorized based on their TyG index. The primary outcome of this study was the incidence of delirium. The TyG indices were quartile and Kaplan -Meier (K-M) cumulative curve was conducted to compare the consequence of each group. Cox proportional hazards and restricted cubic spline (RCS) analyses were employed to explore the associations between TyG indices and outcomes. To mitigate potential biases, a no-replacement propensity score matching (PSM) approach was employed. Subgroup analyses were conducted to explore differences across various demographic and clinical categories.A positive correlation between the quartile groupings of TyG-AVG and an increased cumulative incidence of delirium in individuals with severe AKI, as demonstrated through K-M cumulative curves and Cox regression analysis. Regarding the TyG index, patients in the 4th group displayed the highest hazard of delirium in both of the methods mentioned above. Furthermore, RCS analysis indicated that the interaction between the two variables is approximately linear. Subgroup analyses revealed that the effects of both metrics remained consistent across most examined subgroups.Higher TyG indices were clearly associated with the incidence of delirium in patients with severe AKI. These indices could serve as valuable tools for identifying delirium-prone individuals with AKI.
Keywords: delirium1, acute kidney injury2, intensive care unit3, triglyceride-glucose indices4, insulin resistance5, Cox proportional hazard6 Delirium, Acute Kidney Injury, Intensive Care Unit
Received: 03 Nov 2024; Accepted: 24 Mar 2025.
Copyright: © 2025 Zhang, Jin and Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Tao Jin, School of Medicine, Anhui University of Science and Technology, Huainan, China
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