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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Renal Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1519993

COVID-19 in Discharged Patients with Diabetes and Chronic Kidney Disease: One-year Follow-up and Evaluation

Provisionally accepted
Fang Liu Fang Liu 1*Enrong Ran Enrong Ran 1Yutong Zou Yutong Zou 1Chuanyi Zhao Chuanyi Zhao 2Kai Liu Kai Liu 1Jiamin Yuan Jiamin Yuan 1Wenjie Yang Wenjie Yang 3Lijun Zhao Lijun Zhao 1Qing Yang Qing Yang 1Jia Yang Jia Yang 1Xuegui Ju Xuegui Ju 1Linli Cai Linli Cai 1Yanlin Lang Yanlin Lang 1Xingyuan Li Xingyuan Li 2Ke Liu Ke Liu 1
  • 1 Department of Nephrology, West China Hospital, Sichuan University, Chengdu, China
  • 2 Department of Clinical Research Management, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
  • 3 Division of Project Design and Statistics, West China Hospital,Sichuan University, ChengDu,SiChuan, China

The final, formatted version of the article will be published soon.

    To evaluate the all-cause mortality rate and renal outcomes in patients with diabetes and chronic kidney disease (CKD) following hospital discharge for COVID-1 9.Methods: This single-center prospective observational study included 187 discharged C OVID-19 patients with diabetes and CKD, admitted between December 2022 and Janu ary 2023 at West China Hospital, Sichuan University. Cox regression analysis was use d to assess mortality risk, and logistic regression was applied to identify risk factors f or rapid CKD progression after discharge.Results: During the one-year follow-up, the all-cause mortality rate was 26.7%, with a COVID-19-related acute kidney injury (AKI) incidence of 35.3%, and 35.8% of patie nts experienced rapid CKD progression after discharge. Cox proportional hazards regre ssion indicated that sepsis and mechanical ventilation were major risk factors for postdischarge all-cause mortality. Logistic regression identified baseline eGFR < 60 mL/mi n/1.73 m² as an independent risk factor for rapid CKD progression.Conclusions: During the one-year follow-up period, we observed that patients with diabetes and CKD exhibited higher all-cause mortality and experienced rapid deterioration of kidney function after acute infection with COVID-19. This underscores the importance of ongoing longitudinal follow-up to more accurately track the long-term health effects of COVID-19 on patients with diabetes and CKD.

    Keywords: COVID-19, diabetes, Chronic Kidney Disease, Acute Kidney Injury, Morta lity

    Received: 30 Oct 2024; Accepted: 15 Jan 2025.

    Copyright: © 2025 Liu, Ran, Zou, Zhao, Liu, Yuan, Yang, Zhao, Yang, Yang, Ju, Cai, Lang, Li and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Fang Liu, Department of Nephrology, West China Hospital, Sichuan University, Chengdu, China

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