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ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Clinical Diabetes
Volume 16 - 2025 |
doi: 10.3389/fendo.2025.1516328
This article is part of the Research Topic Advances in Diabetes and Hypertension Research View all 7 articles
Triglyceride-glucose index is associated with a higher risk of hypertension: evidence from a cross-sectional study of Chinese adults and meta-analysis of epidemiology studies
Provisionally accepted
Xiaoli Ren 1,2 Mengying Chen 1,2 Liyou Lian 1
Huimin Xia 1 Shengjie Ge 1 Lijuan Yang 1 Wei Chen 2
Qingxi Jiang 2
XueJiang Gu 1*
Bo Yang 2*
Xiang Hu 1*- 1 First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
- 2 Wenzhou Medical University, Wenzhou, Zhejiang Province, China
Background: Results of population-based studies showed a diverse association between triglyceride-glucose (TyG) index and hypertension. The present study aimed to investigate this association based on a cross-sectional study of Chinese adults and meta-analysis of epidemiology studies. Methods: The cross-sectional analysis used the baseline data from the on-going REACTION study in China. TyG index was calculated as Ln (triglyceride[mg/dl]×fasting plasma glucose[mg/dl]/2). Multivariate-adjusted logistic regression model was used to calculate the odds ratio (OR) with their 95% confidence intervals (CI) for the prevalent hypertension, with the lowest TyG quartile as a reference. Results: A total of 4,177 participants aged 58.62±8.40 years were included. TyG was significantly associated with the higher odds of hypertension (OR:1.273, 95% CI:1.171-1.384), and the association remained pronounced with isolated systolic hypertension (OR:1.161, 95% CI:1.045-1.289) and systolic-diastolic hypertension (OR:1.313, 95% CI:1.163-1.483) but not with isolated diastolic hypertension (OR:1.164, 95% CI:0.929-1.460). In the present meta-analysis, 34 relevant studies were included through systematic searches of PUBMED, Embase, and Cochrane Library. The positive associations between TyG index and hypertension were revealed in the meta-analysis of cohort studies (HR:1.57, 95% CI:1.25-1.96) and cross-sectional studies (OR:2.01, 95% CI:1.47-2.76). Conclusion: Elevated levels of TyG index was significantly associated with higher risk of clinical hypertension, which may have provided the new insights into the clinical management of hypertension.
Keywords: Hypertension, Triglyceride-glucose index, Insulin Resistance, Meta-analysis, Cross-sectional analysis
Received: 24 Oct 2024; Accepted: 21 Jan 2025.
Copyright: © 2025 Ren, Chen, Lian, Xia, Ge, Yang, Chen, Jiang, Gu, Yang and Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
XueJiang Gu, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
Bo Yang, Wenzhou Medical University, Wenzhou, 325035, Zhejiang Province, China
Xiang Hu, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
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