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CLINICAL TRIAL article

Front. Endocrinol.
Sec. Clinical Diabetes
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1515212

The correlation between high-sensitivity cardiac troponin levels in diabetic patients' serum and lower limb lesions: based on NHANES data

Provisionally accepted
Lin Li Lin Li 1,2Linxi Jiao Linxi Jiao 1,2Danyang Yang Danyang Yang 1,2*Jingxia Zhao Jingxia Zhao 1,2*Ping Li Ping Li 1,2*
  • 1 Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China
  • 2 Beijing Institute of Traditional Chinese Medicine, Dongcheng, Beijing, China

The final, formatted version of the article will be published soon.

    Objective: To evaluate the association of hypersensitive cardiac troponin (hs-cTnT), a biomarker of myocardial injury, with diabetic lower extremity disease in American adults.Methods: We conducted a cross-sectional study (unweighted N=1,196) of diabetic patients aged 40 years or older who participated in the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2004. Logistic regression was used to assess the association of hs-cTnT with lower extremity disease, including peripheral neuropathy (as assessed by monofilament test), peripheral artery disease (as assessed by ankle-brachial index), history of foot ulcers, or amputation. All analyses are weighted. Results: The prevalence rate of diabetic lower extremity disease was 41.6%. Adjusted hs-cTnT was significantly associated with lower limb disease in adults with diabetes. There is interaction between chronic kidney disease and hs-cTnT, which strongly interferes with the correlation between hs-cTnT and lower extremity lesions in diabetic patients. Conclusions: Our study suggests the usefulness of hs-cTnT as a biomarker for lower extremity lesions in adults with diabetes and highlights the potential direct interaction of hs-cTnT with chronic kidney disease.

    Keywords: hypersensitive cardiac troponin, Diabetes Mellitus, lower extremity disease, peripheral neuropathy, Peripheral Vascular Disease

    Received: 22 Oct 2024; Accepted: 07 Jan 2025.

    Copyright: © 2025 Li, Jiao, Yang, Zhao and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Danyang Yang, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China
    Jingxia Zhao, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China
    Ping Li, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.