94% of researchers rate our articles as excellent or good
Learn more about the work of our research integrity team to safeguard the quality of each article we publish.
Find out more
ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Renal Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1514067
This article is part of the Research Topic Vascular Dysfunction and Endocrine Disorders View all 6 articles
Association between RC/HDL-C and hyperuricemia in adults: evidence from NHANES 2005-2018
Provisionally accepted- 1 Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences Tongji Shanxi Hospital, Taiyuan, 030032, China, Taiyuan, China
- 2 Department of Cardiovascular Surgery, Shanxi Bethune Hospital, Shanxi Academy of Medical Science, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, 030032, China, Taiyuan, China
BackgroundThe incidence of hyperuricemia is growing in the world, with a significant influence on the survival and healthy condition of the patient. The connection between serum residual cholesterol (RC) to high-density lipoprotein cholesterol (HDL-C) ratio and hyperuricemia is uncertain. Consequently, we tried to elucidate the connection between the hyperuricemia and RC/HDL-C ratio.MethodsBased on the National Health and Nutrition Examination Survey (NHANES) database, data from 2005 to 2018 were utilized in this cross-sectional research. RC/HDL-C index was calculated by (TC - HDL-C - LDL-C) /HDL-C. Participants were diagnosed with hyperuricemia when the serum uric acid concentration reached 6 mg/dL in women and 7 mg/dL in men. Our researcher utilized smoothed curve fitting and multivariate logistic regression analysis to examine between RC/HDL-C and hyperuricemia among adults. The consistency of these results was examined in various population subgroups.Results2376 individuals (19.1%) were stratified into the hyperuricemia group. We observed statistically significant differences (P values < 0.05) in the hyperuricemia population for remaining variables, except for economic level and alcohol drinking. After correcting for potential confounders, our researchers discovered the strong positive connection between the RC/HDL-C and the possibility of incurring hyperuricemia. The incidence of RC/HDL-C elevated by 98% with each additional unit of the RC/HDL-C. Subgroup analyses showed correlations for the majority of subgroups remained stable. However, gender and several diseases may modify this association.ConclusionsHigher RC/HDL-C is correlated with higher prevalence rate of developing hyperuricemia. However, further research is still required to confirm the causal association.
Keywords: Hyperuricemia, RC/HDL-C, Lipid Metabolism, NHANES, population-based studies
Received: 19 Oct 2024; Accepted: 10 Feb 2025.
Copyright: © 2025 Tai, Chen, Kong and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xuening Wang, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences Tongji Shanxi Hospital, Taiyuan, 030032, China, Taiyuan, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.