Animal Models in the Study of Diabetic Erectile Dysfunction: Mechanisms and Applications

鑫 张 ¹ Yihao Chen ¹ Jiahua Qian ² Yuhe Si ² Chenxi Wang ² Jingwei Wang ³ Qiang He ^4* Jianxiong Ma ^4*

• ¹ Second Clinical Medical School, Zhejiang Chinese Medical University, Hangzhou, Jiangsu Province, China
• ² First College of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China
• ³ Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China
• ⁴ First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China

Background: Diabetic erectile dysfunction (DMED) is a common complication of diabetes. While research on DMED relies primarily on animal models, replicating the intricate etiology and multisystem interactions of human DMED in a single model remains a challenge.This article provides a comprehensive overview of animal models used in DMED research and emphasizes the crucial role they play in understanding the pathogenesis and treatment of DMED.Methods: A comprehensive medical literature was searched in PubMed and Medline, focusing on original studies and systematic reviews of original studies involving animal models of diabetic erectile dysfunction. Clinical studies, editorials, letters, reviews, and non-English articles were excluded.Results: This article compiles various animal models currently used in the study of diabetes and diabetic erectile dysfunction (DMED), with a particular emphasis on the application of rodent models such as rats and mice. These animals demonstrate significant advantages in terms of economy, practicality, and reproducibility in DMED research and share similarities with humans in tissue morphology and functional characteristics.This manuscript offers researchers multiple insights into selecting animal models for DMED, particularly considering their practicality, cost-effectiveness, and reproducibility. The integrated information serves as a valuable reference for researchers in choosing suitable models.