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ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Cardiovascular Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1511319
The comprehensive effects of high-sensitivity C-reactive protein and triglyceride glucose index on cardiometabolic multimorbidity
Provisionally accepted
Bingen Wan 
Silin Wang 
Sheng Hu 
WEIQING HAN 
Shengyu Qiu Lingxiao Zhu 
Liancheng Ruan 
Yiping Wei *
Jianjun Xu *- Second Affiliated Hospital of Nanchang University, Nanchang, China
Background：The triglyceride-glucose index (TyG index) is one of the surrogate markers of insulin resistance, and high-sensitivity C-reactive protein (hsCRP) reflects systemic inflammation. Existing studies suggest that insulin resistance or systemic inflammation may be indicative of cardiometabolic disease, but few of the existing studies have combined the TyG index and inflammation levels before assessing cardiometabolic multimorbidity. Our study data came from the China Health and Retirement Longitudinal Study (CHARLS). Participants in this data were followed for 9 years, and we used these data to conduct a long-term analysis to assess the combined effects of the TyG index and hsCRP on cardiometabolic multimorbidity in Chinese adults over 45 years of age.To study the combined effect of TyG index and hsCRP on cardiometabolic multimorbidity in middle-aged as well as elderly Chinese.The study data came from the China Health and Retirement Longitudinal Study (CHARLS), which included a total of 4,483 middle-aged and elderly participants who did not have cardiovascular metabolic diseases at baseline, which was from CHARLS 2011, and the last survey was in 2020. A total of five cardiometabolic diseases were considered in this study: diabetes, hypertension, hyperlipidemia, heart disease and stroke. A person was defined as having cardiometabolic multimorbidity when he/she had two or more cardiometabolic diseases at the same time. TyG index (median as cutoff) and hsCRP (1mg/L as cut-off) were each divided into two groups and combined
Keywords: cardiometabolic multimorbidity (CMM), Triglyceride glucose index (TyG index), Insulin resistance (IR), Inflammation, High-sensitivity C-reactive protein
Received: 14 Oct 2024; Accepted: 10 Mar 2025.
Copyright: © 2025 Wan, Wang, Hu, HAN, Qiu, Zhu, Ruan, Wei and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yiping Wei, Second Affiliated Hospital of Nanchang University, Nanchang, China
Jianjun Xu, Second Affiliated Hospital of Nanchang University, Nanchang, China
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