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ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Endocrinology of Aging
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1511232
Associations between different triglyceride glucose index-related obesity indices and sarcopenia: a cross-sectional study
Provisionally accepted- 1 Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China
- 2 Department of Spine, Wuxi Affiliated Hospital of Nanjing University of Chinese Medicine, Wuxi Jiangsu 214072, China, Wuxi, China
The relationship of triglyceride glucose (TyG) index-related obesity indices with sarcopenia has not been studied in the U.S. population.This cross-sectional survey utilizes data collected from the National Health and Nutrition Examination Survey spanning 2011 to 2018. The correlation between TyG-waist-to-height ratio (TyG-WHtR), TyG-weight-adjusted waist index (TyG-WWI), TyG-waist circumference (TyG-WC), TyG-body mass index (TyG-BMI), and sarcopenia was analyzed by weighted multivariate logistic regression using smoothed curves fitted to the observed nonlinear relationships, and subgroup analysis was performed as well as an interaction test. Ultimately, the diagnostic validity of the four indices was evaluated in comparison with the TyG index for sarcopenia utilizing receiver operating characteristic (ROC) analysis. Results: This study included a total of 4804 participants, with 428 of those diagnosed with sarcopenia. The study illustrated that TyG-WHtR, TyG-WWI, TyG-BMI, and TyG-WC demonstrated a notable positive association with the odds of sarcopenia prevalence.
Keywords: NHANES, Cross-sectional study, Sarcopenia, TyG index, TyG-related obesity index
Received: 14 Oct 2024; Accepted: 24 Feb 2025.
Copyright: © 2025 Xiao, Xu, Liao, Xu, Fan, Li and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xian Zhang, Department of Spine, Wuxi Affiliated Hospital of Nanjing University of Chinese Medicine, Wuxi Jiangsu 214072, China, Wuxi, China
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