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ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Gut Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1508473
This article is part of the Research Topic The Mechanism in Gut Microbiota of Diabetes and Endocrine Complications: Preventive and Therapeutic Target View all 10 articles
Animal studies on the modulation of differential efficacy of polyethylene glycol loxenatide by intestinal flora
Provisionally accepted
Wenjiao Dang Wenjiao Dang 
Wang Yurou Wang Xie Jiaqi Xie He Yan He Ji Hongfang Ji Chen Min Chen Guo Jianjin Guo *- Shanxi Bethune Hospital, Shanxi Medical University, Taiyuan, China
Background:Gut microbiota has demonstrated an increasingly important role in the onset and development of type 2 diabetes mellitus (T2DM), Further investigations have revealed the interactions between drugs and the gut microbiome. However, there are still gaps in research regarding the potential interactions between the gut microbiota and GLP-1 and their therapeutic response in people with T2DM. In addition, Fecal microbiota transplantation (FMT) has become a promising strategy for patients with T2DM.
Keywords: type 2 diabetes, intestinal flora, GLP-1 receptor agonists, polyethylene glycol exenatide, fecal microbiota transplantation, 16S rDNA
Received: 09 Oct 2024; Accepted: 24 Mar 2025.
Copyright: © 2025 Wenjiao Dang, Wang, Xie, He, Ji, Chen and Guo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Guo Jianjin Guo, Shanxi Bethune Hospital, Shanxi Medical University, Taiyuan, China
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