95% of researchers rate our articles as excellent or good
Learn more about the work of our research integrity team to safeguard the quality of each article we publish.
Find out more
ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Cardiovascular Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1506964
Correlation Analysis between Serum Uric Acid and Carotid Intima-Media Thickness: A Cross Sectional Study
Provisionally accepted- 1 School of Clinical Medicine, Jining Medical University, Jining, Shandong, China
- 2 Department of Neurology, Jining First People's Hospital, Jining, China
- 3 Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, China
- 4 Department of Medical Imaging, Affiliated Hospital of Jining Medical University, Jining, Shandong Province, China
Objective: This study aims to investigate the association between serum uric acid (UA) and carotid intima-media thickness (CIMT) in adults undergoing routine health screenings.Methods: Clinical data from 375 participants (mean age: 64.26 ± 9.97 years; 48.53% male) who underwent health examinations at Jining Medical University Affiliated Hospital (January 2022–January 2023) were analyzed. Generalized additive models and piecewise linear regression were used to evaluate linear/non-linear relationships and threshold effects.Results: The study included a total of 375 individuals, with an average age of 64.26 ± 9.97 years. The participants consisted of 48.53% males. After adjusting for confounding factors (age, sex, BMI, etc.), a non-linear relationship between UA and CIMT was identified. The threshold occurred at UA = 3.15 mg/dL. When UA ≥ 3.15 mg/dL, each 1 mg/dL increase in UA was associated with a 0.061 mm increase in CIMT (β = 0.061, 95% CI: 0.031–0.090, p < 0.0001). No significant association was observed when UA < 3.15 mg/dL (β = −0.002, 95% CI: −0.033–0.030, p = 0.9240).Conclusion:The study demonstrates a non-linear relationship between UA and CIMT in the health screening population. UA levels ≥3.15 mg/dL are positively correlated with increased CIMT, suggesting that elevated UA may promote carotid atherosclerosis progression.
Keywords: Intima media thickness, Uric Acid, carotid atherosclerosis, cerebrovascular disease, Cross Sectional Study Abstract
Received: 06 Oct 2024; Accepted: 02 Apr 2025.
Copyright: © 2025 Zhang, Zhang, Yu, Ji, Zhang, Wang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Hongjun Wang, Department of Medical Imaging, Affiliated Hospital of Jining Medical University, Jining, Shandong Province, China
Daojing Li, Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.