The final, formatted version of the article will be published soon.
ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Cardiovascular Endocrinology
Volume 16 - 2025 |
doi: 10.3389/fendo.2025.1506884
This article is part of the Research Topic Re-visiting Risk Factors for Cardiometabolic Diseases: Towards a New Epidemiological Frontier View all 18 articles
Association Between Life's Essential 8 and Atherogenic Index of Plasma in Adults: Insights from NHANES 2007-2018
Provisionally accepted
Longhui Xu 1
Kaiwen Ding 1*
杨 国栋 2 Xiaoxuan Han 2* Xiao Cong 2* Ronghui Wang 2* Xinru Liu 2* Na Li 2* Cuiping Xu 1*- 1 Department of Nursing, Shandong Provincial Qianfoshan Hospital, Jinan, Shandong Province, China
- 2 Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China
Objectives: This study aimed to investigate the relationship between Life's Essential 8 (LE8) and the Atherogenic Index of Plasma (AIP). Methods: We conducted an analysis of data from 8,215 U.S. adults aged 20 years and older, utilizing the National Health and Nutrition Examination Survey (NHANES) data from 2007 to 2018. Based on the LE8 score, Cardiovascular Health (CVH) was classified into three levels-low, moderate, and high-while AIP was classified into four risk levels: extremely low (AIP<-0.3), low (-0.3≤AIP<0.1), medium (0.1≤AIP<0.24), and high (AIP≥0.24).Weighted ordinal logistic regression analysis was utilized to examine the association between the LE8 score and the AIP risk level, adjusting for potential confounding variables. Results: A significant negative correlation exists between the LE8 score and the AIP risk level (OR=0.51, 95%CI: 0.49-0.54, P<0.001). Higher CVH were associated with lower AIP risk levels, while lower CVH corresponded to elevated AIP risk levels. Notably, improvements in specific LE8 components-such as body mass index and blood lipids-exhibited a strong relationship with reductions in the AIP risk level. Conclusions: This study suggests that the LE8 may serve as a preventive factor for cardiovascular disease risk and implies that individuals can actively regulate their metabolic characteristics by optimizing their lifestyle.
Keywords: Life's Essential 8, Atherogenic index of plasma, Cardiovascular health, cardiovascular disease, NHANES
Received: 06 Oct 2024; Accepted: 31 Jan 2025.
Copyright: © 2025 Xu, Ding, 国栋, Han, Cong, Wang, Liu, Li and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Kaiwen Ding, Department of Nursing, Shandong Provincial Qianfoshan Hospital, Jinan, 250014, Shandong Province, China
Xiaoxuan Han, Shandong University of Traditional Chinese Medicine, Jinan, 250355, Shandong Province, China
Xiao Cong, Shandong University of Traditional Chinese Medicine, Jinan, 250355, Shandong Province, China
Ronghui Wang, Shandong University of Traditional Chinese Medicine, Jinan, 250355, Shandong Province, China
Xinru Liu, Shandong University of Traditional Chinese Medicine, Jinan, 250355, Shandong Province, China
Na Li, Shandong University of Traditional Chinese Medicine, Jinan, 250355, Shandong Province, China
Cuiping Xu, Department of Nursing, Shandong Provincial Qianfoshan Hospital, Jinan, 250014, Shandong Province, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.