The Rising Burden of Diabetes and Statewise Variations in India: Insights and projections to 2031 from the Global Burden of Disease Study 1990-2021

Shubham Chauhan¹Mahalaqua Nazli Khatib²Suhas Ballal³Pooja Bansal⁴Kiran Bhopte⁵Abhay M Gaidhane²Balvir S Tomar⁶Ayash Ashraf⁷M Ravi Kumar⁸Ashish Singh Chauhan⁹Muhammed Shabil¹⁰Diptismita Jena¹¹Ganesh Bushi¹²Shailesh Kumar Samal^13*Lara Jain¹¹Vaibhav Jaiswal⁵Manvi Pant¹⁴

• ¹Global Center for Evidence Synthesis (GCES), Chandigarh, Haryana, India
• ²Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India
• ³Jain University, Bengaluru, Karnataka, India
• ⁴Vivekananda Global University, Jaipur, Rajasthan, India
• ⁵IES Institute of Pharmacy, IES University, Bhopal, Madhya Pradesh, India
• ⁶NIMS University, Jaipur, Rajasthan, India
• ⁷Chandigarh Group of Colleges, Mohali, Punjab, India
• ⁸Raghu Engineering College, Visakhapatnam, Andhra Pradesh, India
• ⁹Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, Uttarakhand, India
• ¹⁰Chandigarh University, Mohali, Punjab, India
• ¹¹Graphic Era University, Dehradun, Uttarakhand, India
• ¹²Lovely Professional University, Phagwara, Punjab, India
• ¹³Karolinska Institutet (KI), Solna, Sweden
• ¹⁴New Delhi Institute of Management, New Delhi, India

Background: Diabetes is a major public health concern in India, contributing significantly to morbidity and mortality. With variations in disease burden across states, a detailed understanding of trends in incidence, prevalence, and Disability Adjusted Life Years (DALYs) is essential for targeted interventions.Methods: This study utilized Global Burden of Disease (GBD) data from 1990 to 2021 to examine trends in diabetes across Indian states. Age-standardized incidence, prevalence, mortality, and DALYs were analyzed using Join point regression to estimate Annual Percentage Change (APC). Autoregressive Integrated Moving Average (ARIMA) models were employed to project diabetes trends up to 2031.While the GBD data provide robust national and regional estimates, their modeled nature may not capture the full spectrum of local epidemiological variations.Results: Diabetes incidence increased from 162.74 to 264.53 per 100,000 between 1990 and 2021, with an APC of 0.63%. Joinpoint analysis identified episodic surges in incidence, with APCs of 2.25% during 1996-1999 and 2.07% during 2005-2011, suggesting intervals of accelerated increase relative to the gradual progression typically observed in chronic conditions. Mortality rose from 23.09 to 31.12 per 100,000 (APC: 0.12%). Southern and Western states, such as Tamil Nadu and Goa, exhibited the highest prevalence and DALYs. Forecasted trends indicate that by 2031, the prevalence will reach 8585.45 per 100,000, and DALYs will exceed 1241.57 per 100,000. States like Bihar and Jharkhand showed moderate changes, while Goa had the highest rise in prevalence.The burden of diabetes in India has significantly increased, particularly in Southern and Western regions.risen markedly over the past three decades. These findings highlightunderscore the urgent need for region-specific health policies focused onthat emphasize lifestyle modifications and enhancedimproved healthcare access. Tailored interventions targeting high-burden states are crucialA comprehensive approach that integrates primary prevention through community-based health education, dietary counseling, and initiatives to promote physical activity with secondary prevention measures such as systematic screening and timely clinical management, is essential for effective diabetes control and management in high-burden states.