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REVIEW article

Front. Endocrinol.
Sec. Neuroendocrine Science
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1500650

Research progress on the mechanism and markers of metabolic disorders in the occurrence and development of cognitive dysfunction after ischemic stroke

Provisionally accepted
Huaqiang LI Huaqiang LI 1,2Xiaohua Ke Xiaohua Ke 2Bianying Feng Bianying Feng 3*huan Tian huan Tian 1,2Zhenzhen Cai Zhenzhen Cai 3*Anren Zhang Anren Zhang 2*Qiuhong Man Qiuhong Man 3*
  • 1 School of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China
  • 2 Department of Rehabilitation Medicine, Shanghai Fourth People's Hospital, Shanghai, Shanghai Municipality, China
  • 3 Department of Clinical Laboratory, Shanghai Fourth People's Hospital, Shanghai, Shanghai Municipality, China

The final, formatted version of the article will be published soon.

    Post-stroke cognitive impairment (PSCI) is a common complication following a stroke that significantly affects patients' quality of life and rehabilitation outcomes. It also imposes a heavy economic burden. There is an urgent need to better understand the pathophysiology and pathogenesis of PSCI, as well as to identify markers that can predict PSCI early in the clinical stage, facilitating early prevention, monitoring, and treatment. Although the mechanisms underlying PSCI are complex and multifaceted, involving factors such as atherosclerosis and neuroinflammation, metabolic disorders also play a critical role. This article primarily reviews the relationship between metabolic disorders of the three major nutrients-sugar, fat, and protein-and the development of cognitive dysfunction following ischemic stroke (IS). It aims to elucidate how these metabolic disturbances contribute to cognitive dysfunction post-stroke and to explore potential metabolic biomarkers for PSCI. We believe that this review will offer new insights into the early identification, treatment, and prognostic assessment of PSCI.

    Keywords: ischemic stroke, cognitive dysfunction, metabolic disorders, biomarker, Review Ischemic stroke

    Received: 24 Sep 2024; Accepted: 03 Jan 2025.

    Copyright: © 2025 LI, Ke, Feng, Tian, Cai, Zhang and Man. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Bianying Feng, Department of Clinical Laboratory, Shanghai Fourth People's Hospital, Shanghai, Shanghai Municipality, China
    Zhenzhen Cai, Department of Clinical Laboratory, Shanghai Fourth People's Hospital, Shanghai, Shanghai Municipality, China
    Anren Zhang, Department of Rehabilitation Medicine, Shanghai Fourth People's Hospital, Shanghai, Shanghai Municipality, China
    Qiuhong Man, Department of Clinical Laboratory, Shanghai Fourth People's Hospital, Shanghai, Shanghai Municipality, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.