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REVIEW article
Front. Endocrinol.
Sec. Reproduction
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1495746
Adipokines in Focus: Predicting Gestational Diabetes Mellitus through Emerging Biomarkers
Provisionally accepted- Sheng Jing Hospital Affiliated, China Medical University, Shenyang, China
Gestational diabetes mellitus (GDM) is characterised by any degree of glucose intolerance that manifests, or is first recognised, during pregnancy. It is a condition that can have deleterious consequences for both the mother and fetus. Adipokines are a group of proteins or molecules secreted from adipocytes that regulate blood glucose and energy metabolism.At present, research into the relationship between adipokines and GDM is a research hotspot. Recent studies have revealed an important role of adipokines in the pathophysiological mechanisms of GDM, with some potentially being predictors of the early stages of GDM (e.g., adiponectin and leptin).However, the accuracy of several new adipokines in the pathogenesis of GDM remains uncertain. (e.g.,nesfatin-1,neuregulin 4(NRG4),retinol binding protein-4, omentin-1, resistin,chemerin, visfatin, vaspin, apelin,asprosin,secreted frizzled-related protein 5, lipocalin-2 and C1QTNF-related proteins. Consequently, further research is required to elucidate the pathogenesis of GDM. This review summarises the recent advancements in research on novel adipokines that have the potential to predict GDM. These findings may contribute to enhancing the efficiency of GDM screening, as well as the treatment or prevention of this condition.
Keywords: gestational diabetes mellitus, Adipokines, glucose metabolism, biomarker, Insulin
Received: 13 Sep 2024; Accepted: 04 Feb 2025.
Copyright: © 2025 Haoyue, Li and Ling. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ping Li, Sheng Jing Hospital Affiliated, China Medical University, Shenyang, China
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