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ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Cardiovascular Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1489325
This article is part of the Research Topic Advances in Diabetes and Hypertension Research View all 10 articles
Childhood Triglyceride-glucose Index and Pre-Hypertension in Adulthood:A Prospective Cohort Study
Provisionally accepted- Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China
BACKGROUND: The triglyceride-glucose (TyG) index serves as a surrogate marker for insulin resistance. Multiple studies have demonstrated a positive correlation between the TyG index and blood pressure, indicating that a high TyG index is related to a greater risk of developing pre-hypertension (pre-HTN) and hypertension (HTN). However, the relationship between changes in the TyG index during childhood and pre-HTN in adulthood requires further clarification.METHODS: The present prospective study utilized data from the Bogalusa Heart Study, a long-term follow-up study. Data on triglycerides (TG), fasting glucose (Fg), and low-density lipoprotein cholesterol (LDL-C) were collected from cross-sectional examinations of participants during childhood. Blood pressure (BP) in early adulthood was categorized into normotensive and pre-HTN groups. Logistic regression was employed to evaluate the relationship between the TyG index in childhood and pre-HTN in adulthood.
Keywords: Triglyceride-glucose index, Pre-hypertension, race, gender, cohort study
Received: 31 Aug 2024; Accepted: 24 Mar 2025.
Copyright: © 2025 Zhao, Cui, Ouyang, Qu and Gao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Hua Qu, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China
Zhuye Gao, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China
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