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REVIEW article

Front. Endocrinol.
Sec. Bone Research
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1488489

Interruption of mitochondrial symbiosis is associated with the development of osteoporosis

Provisionally accepted
Zhang Haoling Zhang Haoling 1,2,3ZHAO Rui ZHAO Rui 3*Wang Xuemei Wang Xuemei 3*Qi Yaqian Qi Yaqian 3*Sandai Doblin Sandai Doblin 2*Wang Wei Wang Wei 3*Zhijing Song Zhijing Song 3*LIANG Qiudong LIANG Qiudong 1*
  • 1 The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan Province, China
  • 2 Advanced Medical and Dental Institute, University of Science Malaysia (USM), Penang, Malaysia
  • 3 Gansu University of Chinese Medicine, Lanzhou, Gansu, China

The final, formatted version of the article will be published soon.

    Mitochondria maintain bacterial traits because of their endosymbiotic origins, yet the host cell recognizes them as non-threatening since the organelles are compartmentalized.Nevertheless, the controlled release of mitochondrial components into the cytoplasm can initiate cell death, activate innate immunity, and provoke inflammation. This selective interruption of endosymbiosis as early as 2 billion years ago allowed mitochondria to become intracellular signaling hubs. Recent studies have found that the interruption of mitochondrial symbiosis may be closely related to the occurrence of various diseases, especially osteoporosis (OP). OP is a systemic bone disease characterized by reduced bone mass, impaired bone microstructure, elevated bone fragility, and susceptibility to fracture. The interruption of intra-mitochondrial symbiosis affects the energy metabolism of bone cells, leads to the imbalance of bone formation and bone absorption, and promotes the occurrence of osteoporosis. In this paper, we reviewed the mechanism of mitochondrial intersymbiosis interruption in OP, discussed the relationship between mitochondrial intersymbiosis interruption and bone marrow mesenchymal stem cells, osteoblasts and osteoclasts, as well as the inheritance and adaptation in the evolutionary process, and prospected the future research direction to provide new ideas for clinical treatment.

    Keywords: Interruption of mitochondrial endosymbiosis, Osteoporosis, Cytoplasmic signal, Bone tissue cells, Heredity, ADAPT, targeted therapy

    Received: 30 Aug 2024; Accepted: 14 Jan 2025.

    Copyright: © 2025 Haoling, Rui, Xuemei, Yaqian, Doblin, Wei, Song and Qiudong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    ZHAO Rui, Gansu University of Chinese Medicine, Lanzhou, 730000, Gansu, China
    Wang Xuemei, Gansu University of Chinese Medicine, Lanzhou, 730000, Gansu, China
    Qi Yaqian, Gansu University of Chinese Medicine, Lanzhou, 730000, Gansu, China
    Sandai Doblin, Advanced Medical and Dental Institute, University of Science Malaysia (USM), Penang, Malaysia
    Wang Wei, Gansu University of Chinese Medicine, Lanzhou, 730000, Gansu, China
    Zhijing Song, Gansu University of Chinese Medicine, Lanzhou, 730000, Gansu, China
    LIANG Qiudong, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453100, Henan Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.