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CASE REPORT article
Front. Endocrinol.
Sec. Neuroendocrine Science
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1487375
Case report: management of a patient with Sheehan's syndrome presenting with anxiety and depression
Provisionally accepted- Jinhua Central Hospital, Jinhua, China
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Sheehan's syndrome is a rare and under-recognized disorder that may be encountered in a variety of clinical settings. The diagnosis of the condition is challenging due to its rarity and the fact that it is often overlooked in differential diagnoses. Furthermore, there are no characteristic clinical features or routine laboratory tests that can immediately inform the diagnosis. We report the case of a 50-year-old woman diagnosed with an anxiety-depressive state who exhibited marked and progressive symptoms, which resolved more rapidly following treatment with escitalopram oxalate and recurred after discontinuation of the medication. Further examination revealed abnormalities in hormone levels and pituitary augmentation MRI, based on which the patient was finally diagnosed with Sheehan's syndrome. This case underscores the rarity of patients with Sheehan's syndrome manifesting with anxiety and depression, thereby presenting a diagnostic challenge to clinicians. The objective of this case report is to emphasize the necessity for heightened awareness among healthcare professionals regarding patients with rare clinical presentations and the significance of timely and collaborative treatment strategies.
Keywords: Sheehan's syndrome, hormone, Anxiety, Depression, case report
Received: 28 Aug 2024; Accepted: 08 Apr 2025.
Copyright: © 2025 Liu, Chen, Feng, Zhu, Luo, Chen and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yuehua Chen, Jinhua Central Hospital, Jinhua, China
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