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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Reproduction
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1486732

Association between Neutrophil Percentage to Albumin Ratio and erectile dysfunction among US males: a population-based cross sectional study

Provisionally accepted
Changjin Liu Changjin Liu *
  • Department of Urology, Kaiping Central Hospital, Kaiping, Jiangmen, China

The final, formatted version of the article will be published soon.

    The purpose of this study was to investigate the relationship between neutrophil percentage to albumin ratio (NPAR) and erectile dysfunction (ED) in adult men in the United States.We conducted a series of statistical analyses of the relationship between the NPAR index and ED prevalence among participants in the 2001-2004 National Health and Nutrition Examination Survey (NHANES) database.Results: A total of 3618 participants were enrolled in this study, of whom 1021 (28.2%) had ED. The NPAR value was 13.2 (95% CI: 11.1, 15.7) in participants without ED while 14.2 (95% CI: 11.6, 16.8) in participants with ED. There was a significant positive correlation between NPAR and ED prevalence (OR=1.21, 95% CI, 1.17,1.26, P<0.001), which remained significant after adjustment for confounding variables(OR=1.06, 95%CI(1.00,1.26), P<0.001).Multiple inference analyses confirmed the robustness of our results. Interaction tests suggested that marital status may influence this positive association. In addition, we observed a U-shaped relationship between NPAR and ED.This large cross-sectional study suggested a statistically significant association between the occurrence of ED and NPAR among US adult males. Further studies are needed to validate these findings and elucidate the specific mechanisms involved.

    Keywords: Neutrophil percentage to albumin ratio, Erectile Dysfunction, NHANES, Cross-sectional study, Inflammation

    Received: 26 Aug 2024; Accepted: 03 Feb 2025.

    Copyright: © 2025 Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Changjin Liu, Department of Urology, Kaiping Central Hospital, Kaiping, Jiangmen, China

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