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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Clinical Diabetes
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1477006
This article is part of the Research Topic Is Insulin Resistance the Eminence Grise of Aging and Non-Communicable Chronic Diseases? View all 4 articles

The relationship of anxiety with cardiometabolic risk factors in adolescents with obesity: propensity scores

Provisionally accepted
Miguel Villasis-Keever Miguel Villasis-Keever 1Jessie Zurita-Cruz Jessie Zurita-Cruz 2*Pichardo-Estrada Areli Pichardo-Estrada Areli 1Wendy Alejandra Mazon-Aguirre Wendy Alejandra Mazon-Aguirre 1
  • 1 Instituto Mexicano del Seguro Social, Mexico City, Mexico
  • 2 Departamento de Epidemiología, Hospital Infantil de México Federico Gómez, Mexico City, Mexico

The final, formatted version of the article will be published soon.

    Background: It has been described that there is a relationship between metabolic health and anxiety.Objective. To determine the relationship between anxiety and metabolic syndrome, as well as cardiometabolic risk factors, in adolescents with obesity.A comparative cross-sectional study of adolescents with obesity between January 2019 and December 2022. In each patient, we recorded somatometric measurements, lipid profile, and serum insulin levels. Anxiety was measured using the Spence Children's Anxiety Scale.Participants were divided into those with and without anxiety. Patients with anxiety were matched to patients without anxiety using propensity scores based on z-score body mass index (zBMI). U Mann Whitney tests and χ 2 tests were used.Results: Of the 564 adolescents, 32.6% (n = 184) suffered from anxiety. In the overall study population, no differences in biochemical and cardiometabolic parameters were observed between adolescents with and without anxiety prior to adjusting the groups based on zBMI. After matching from their zBMI, we found that adolescents with anxiety had higher serum uric acid levels (5.9 mg/dl vs. 5.4 mg/dl, p = 0.041), an increased incidence of metabolic syndrome (39.1% vs. 15.9%, p = 0.002), hyperglycemia (21.7% vs. 8.6%, p = 0.020), and lower HDLc (67.3% vs. 34.7%, p < 0.001), than those without anxiety. Females with anxiety had a higher proportion of cardiometabolic risk factors compared to those without anxiety.Adolescents with obesity and anxiety had higher cardiometabolic risk factors than those without anxiety.

    Keywords: Obesity, Anxiety, metabolic syndrome, Insulin Resistance, cardiometabolic factors Not applicable Obesity, Cardiometabolic factors

    Received: 06 Aug 2024; Accepted: 09 Jan 2025.

    Copyright: © 2025 Villasis-Keever, Zurita-Cruz, Areli and Mazon-Aguirre. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jessie Zurita-Cruz, Departamento de Epidemiología, Hospital Infantil de México Federico Gómez, Mexico City, Mexico

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