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ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Clinical Diabetes
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1475323
This article is part of the Research Topic Advances in Diabetes and Hypertension Research View all 9 articles
Associations of obesity and novel lipid indicators in the risk of type 2 diabetes mellitus in Chinese elderly hypertensive patients
Provisionally accepted
Xihui Jin 1,2
Wei Yushuang 2,3 Yemei Mo 4 Qiuling Zhang 4
Mingjie Xu 1,2
Xiaoyou Mai 2,3
Yan Boteng 1,2 Wenchao Xie 4
Shengzhu Huang 2
Mingli Li 2
Zengnan Mo 2*- 1 Department of Urology, First Affiliated Hospital of Guangxi Medical University, Nanning, China
- 2 Research Center for Genomics and Personalized Medicine, Guangxi Medical University, Nanning, Guangx, China
- 3 School of Public Health, Guangxi Medical University, Nanning, Guangx, China
- 4 The First People’s Hospital of Yulin, Yulin, Shaanxi Province, China
The associations of waist circumference (WC), body mass index (BMI), lipid accumulation product (LAP), Chinese visceral adiposity index (CVAI), and triglyceride-glucose Index (TyG) with the risk of type 2 diabetes mellitus (T2DM) remained uncertain in Chinese middle-aged and elderly hypertensive patients.Methods: A total of 1,965 hypertensive participants aged 45 years and elderly were included in the cross-sectional analysis, and 1,576 hypertensive participants without T2DM for the cohort analysis. In the cross-sectional study, binary logistic regression, restricted cubic splines (RCS), and receiver operating characteristic (ROC) were used to analyze the relationships between WC, BMI, LAP, CVAI, and TyG with and T2DM in hypertensive patients. In the cohort study, Kaplan-Meier survival analyses and Cox regression were further performed to determine the associations of these indicators with incident T2DM risk.In the cohort study, there were 101 incident T2DM cases occurred during a median follow-up of 30 months, with an incident rate was 2.78 per 100 person-years. The cross-sectional study showed that the risk of T2DM increased significantly with higher quartiles of WC, BMI, LAP, CVAI, and TyG (all P-trend < 0.001). In the cohort study, Cox regression model showed that
Keywords: Obesity indices, novel lipid indicators, type 2 diabetes mellitus, elderly hypertensive patients, Chinese community
Received: 03 Aug 2024; Accepted: 12 Mar 2025.
Copyright: © 2025 Jin, Yushuang, Mo, Zhang, Xu, Mai, Boteng, Xie, Huang, Li and Mo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Zengnan Mo, Research Center for Genomics and Personalized Medicine, Guangxi Medical University, Nanning, Guangx, China
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