REVIEW article
Front. Endocrinol.
Sec. Diabetes: Molecular Mechanisms
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1474643
This article is part of the Research TopicVascular Dysfunction and Endocrine DisordersView all 10 articles
Influence of gestational diabetes mellitus on the cardiovascular system and its underlying mechanisms
Provisionally accepted
- 1The First Affiliated Hospital of Soochow University, Suzhou, China
- 2Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China
- 3Taixing People's Hospital, Taixing, China
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Gestational diabetes mellitus (GDM) is one of the most common endocrine-related complications during pregnancy, and its prevalence has increased over the past three decades. Gestational diabetes mellitus adversely affects the maternal cardiovascular system, umbilical-placental blood perfusion, and fetal blood flow. We conducted a comprehensive literature search and systematically evaluated and synthesized cardiovascular changes in the mothers, umbilical-placental circulation, and the progeny following exposure to GDM. Multiple pathophysiological mechanisms underlying cardiovascular alteration were investigated, including endothelial dysfunction, insulin resistance, oxidative stress, ion channels abnormalities, inflammation, angiogenic imbalance, and epigenetic modifications. These findings provide valuable insights for developing early intervention strategies and therapeutic approaches to mitigate cardiovascular risks in both mothers and offspring following GDM exposure.
Keywords: Cardiovascular System, gestational diabetes mellitus, progeny, umbilical-placental circulation, Mother
Received: 05 Aug 2024; Accepted: 23 Apr 2025.
Copyright: © 2025 Zhang, Zhang, Li, Li, Qi, He, Xu and Tang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jiaqi Tang, The First Affiliated Hospital of Soochow University, Suzhou, China
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