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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Reproduction
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1465022
This article is part of the Research Topic Lifestyle and Environmental Factors and Human Fertility View all 8 articles

Higher Life's Crucial 9 protects against infertility among U.S. women aged 18-45 years

Provisionally accepted
Shaoqun Huang Shaoqun Huang 1Shuqin Duan Shuqin Duan 2Seok Choi Seok Choi 3Hongyang Gong Hongyang Gong 3*
  • 1 Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian Province, China
  • 2 Second Affiliated Hospital of Jilin University, Changchun, Jilin Province, China
  • 3 Chosun University, Gwangju, Republic of Korea

The final, formatted version of the article will be published soon.

    Infertility is not only a reproductive issue but is also closely linked to cardiovascular health and other factors. Life's Crucial 9 (LC9) is a set of lifestyle guidelines aimed at improving cardiovascular health, yet its potential association with infertility remains underexplored. This study aims to investigate the relationship between LC9 and infertility, providing new insights and strategies for the prevention and management of infertility.Methods: This study utilized data from the National Health and Nutrition Examination Survey (NHANES) from 2013 to 2018. Multivariate logistic regression and weighted quantile sum (WQS) regressions were employed to investigate the association between LC9 and infertility. Restricted cubic spline (RCS) analysis explored the linear or non-linear relationship between LC9 and infertility. Interaction analyses were conducted on subgroups to validate the findings.Results: There was a significant negative association between LC9 and infertility. After adjusting for covariates, for every 10-point increase in LC9, there was a 35% decrease in the prevalence of infertility (P < 0.001). This negative correlation persisted when LC9 was divided into quartiles.Moreover, as LC9 increased, there was a trend towards lower infertility prevalence (P for trend < 0.001). WQS analyses showed consistent associations (OR=0.27, 95%CI: 0.14, 0.53), with sleep health score, psychological health score, and Body mass index score as significant factors. The dose-response curve indicated a linear association between LC9 and infertility, with higher LC9 associated with lower infertility risk.The results of this study show a strong negative correlation between LC9 and the prevalence of infertility. Clinically, these findings offer hope for infertility patients, suggesting that adherence to a higher LC9 score significantly reduces the risk of infertility. This will provide a new avenue for infertility prevention and management, offering hope and potential relief to infertile patients.

    Keywords: Infertility, Life's Crucial 9, Association, National Health and Nutrition Examination Survey, Cardiovascular health

    Received: 15 Jul 2024; Accepted: 15 Jan 2025.

    Copyright: © 2025 Huang, Duan, Choi and Gong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Hongyang Gong, Chosun University, Gwangju, Republic of Korea

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