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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Pediatric Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1446049
This article is part of the Research Topic Metabolic Associated Fatty Liver Disease (MAFLD) in childhood: a new challenge View all 8 articles

The value of sex hormones and sex hormone-binding globulin in metabolic dysfunction-associated fatty liver disease among boys with obesity

Provisionally accepted
Ying Wang Ying Wang 1Shuyi Yang Shuyi Yang 2Suming Zhang Suming Zhang 2Ye Yang Ye Yang 2Siqing Li Siqing Li 3Meiyu Zhang Meiyu Zhang 3Xiaona Li Xiaona Li 2Hua Bai Hua Bai 4Peiliang Luo Peiliang Luo 4Yingdi Yuan Yingdi Yuan 4*
  • 1 Graduate Training Base of Lianyungang First People’s Hospital of Jinzhou Medical University, The First People’s Hospital of Lianyungang, Lianyungang, China
  • 2 Xuzhou Medical University Affiliated Hospital of Lianyungang, The First People’s Hospital of Lianyungang, Lianyungang, China
  • 3 Lianyungang Clinical College of Nanjing Medical University, The First People’s Hospital of Lianyungang, Lianyungang, China
  • 4 The First People’s Hospital of Lianyungang, Lianyungang, China

The final, formatted version of the article will be published soon.

    Objective:This study aims to investigate the relationship between metabolic dysfunction-associated fatty liver disease (MAFLD) and sex hormones and sex hormone-binding globulin (SHBG) in boys with obesity.Methods: Retrospective analysis of metabolic indicators and sex hormone levels in boys with obesity who sought medical attention at the First People's Hospital of Lianyungang City from January 2020 to December 2023. Based on abdominal ultrasound results, they were categorized into a simple obesity group and MAFLD group , and differences between the two groups were compared. Utilizing logistic regression analysis to explore the risk factors for developing MAFLD, and through the construction of Receiver Operating Characteristic (ROC) curves, conducting a preliminary assessment of the diagnostic value for MAFLD.: A total of 155 male children with obesity were included in the study, mean age of 11.07±1.53 years. Children in the MAFLD group had higher levels of height[ (159.49±12.73)cm vs.(155.55±10.50)cm], weight[(82.32±18.75)kg vs.(68.28±15.00)kg], B

    Keywords: childhood, Obesity, Metabolic dysfunction-associated fatty liver disease (MAFLD), Non-alcoholic fatty liver disease (NAFLD), Sex hormone-binding globulin (SHBG), Testosterone

    Received: 08 Jun 2024; Accepted: 15 Jan 2025.

    Copyright: © 2025 Wang, Yang, Zhang, Yang, Li, Zhang, Li, Bai, Luo and Yuan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yingdi Yuan, The First People’s Hospital of Lianyungang, Lianyungang, China

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