ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Clinical Diabetes
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1443705
This article is part of the Research TopicExploring the New Biomarkers and Clinical Indicators for Diabetes: Insights from Real-World StudiesView all 29 articles
Association between triglyceride glucose index and Helicobacter pylori infection: a cross-sectional study
Provisionally accepted
- 1Hunan University of Chinese Medicine, Changsha, China
- 2Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China
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Background: Mounting research suggests that insulin resistance (IR) is associated with Helicobacter pylori (H. pylori) infection. The triglyceride-glucose (TyG) index has received widespread attention due to its high sensitivity in assessing IR. This study examined the association between H. pylori infection and TyG index. Methods: This cross-sectional study used data from the National Health and Nutrition Examination Survey (NHANES) 1999 -2000. Participants were categorized into groups Q1 -Q4 based on the quartile of their TyG index. Weighted multivariable-adjusted logistic regression and subgroup analysis were used to explore the correlation between TyG index and H. pylori infection. Furthermore, Sensitivity analysis was conducted to assess the robustness of our findings.Results: This study included 2,918 participants, 1,101 of whom were infected with H. pylori. The mean TyG index for all participants was 8.56 ± 0.67. Patients who were H. pylori positive had higher levels of TyG index compared with H. pylori seronegative participants (8.74 ± 0.03 vs. 8.57 ± 0.03, P < 0.05). The fourth quartile of the TyG index showed the highest odds of H. pylori infection compared to Q1 (OR = 2.37, 95%CI: 1.52 to 3.71, P < 0.001). Sensitivity analysis indicated that the association between TyG index and H. pylori infection remained strong even after excluding participants with CVD or taking lipid-lowering medications, as well as patients with diabetes or taking glucose-lowering medications.In this study, a stable and strong positive association was found between TyG index and H. pylori infection. IR may be significantly associated with H. pylori infection. Further studies are necessary to elucidate the underlying mechanisms and potential clinical implications of these findings.
Keywords: Triglyceride glucose (TyG) index, Helicobacter pylori (H. pylori), Insulin Resistance, national Health and Nutrition Examination Survey (NHANES), Cross-sectional study
Received: 04 Jun 2024; Accepted: 31 Mar 2025.
Copyright: © 2025 Long, Mao, Xu and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ying Zhu, Hunan University of Chinese Medicine, Changsha, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
