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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Renal Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1438639
This article is part of the Research Topic Endocrine Imbalances of Mineral Ions and Vitamins in Chronic Disease Pathogenesis View all 13 articles

Association between magnesium depletion score and prevalence of hyperuricemia in American adults: a study based on NHANES 2007-2018

Provisionally accepted
Yongchun Xiao Yongchun Xiao Ping Wu Ping Wu Ke Wang Ke Wang Tianjun Chen Tianjun Chen Zhiwan Chen Zhiwan Chen Hongsheng Lin Hongsheng Lin ZhiShneg Ji ZhiShneg Ji *
  • First Affiliated Hospital of Jinan University, Guangzhou, China

The final, formatted version of the article will be published soon.

    Abstract Background The Magnesium Depletion Score (MDS) is a novel indicator that integrates multiple factors to assess systemic magnesium depletion. However, its association with hyperuricemia (HUA) prevalence remains unclear. This study aims to investigate the relationship between MDS and the prevalence of HUA. Methods A cross-sectional analysis was conducted using data from the 2007-2018 National Health and Nutrition Examination Survey (NHANES). The MDS was derived by integrating multiple risk factors associated with magnesium depletion: the use of diuretics and proton pump inhibitors (PPI), estimated glomerular filtration rate (eGFR), and alcohol consumption exceeding recommended thresholds. Univariable and multivariable logistic regression models assessed the association between MDS and HUA. Subgroup and sensitivity analyses, including the exclusion of gout patients, further evaluated this association. Results Among 18,761 participants, higher MDS were associated with an increased prevalence of HUA. Multivariable logistic regression confirmed a significant positive association between MDS and HUA (OR = 1.73, 95% CI = 1.62-1.84). Restricted cubic splines (RCS) further characterized the non-linear relationship between MDS and HUA prevalence. Subgroup analysis indicated a positive association between MDS and HUA, with significant interactions observed for sex and body mass index. Sensitivity and additional analyses reinforced the robustness of these findings. Conclusion Among U.S. adults, higher MDS were significantly associated with an increased prevalence of HUA, suggesting that interventions targeting magnesium deficiency could be beneficial in reducing HUA prevalence within this population. However, prospective studies are needed to further confirm these findings.

    Keywords: magnesium depletion score, Hyperuricemia, Uric Acid, Cross-sectional study, NHANES

    Received: 26 May 2024; Accepted: 16 Jan 2025.

    Copyright: © 2025 Xiao, Wu, Wang, Chen, Chen, Lin and Ji. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: ZhiShneg Ji, First Affiliated Hospital of Jinan University, Guangzhou, China

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