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ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Clinical Diabetes
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1434745
Elevated plasma concentrations of lipoprotein (a) are associated with cardiovascular diseases in patients with early-onset type 2 diabetes
Provisionally accepted
Juan Zhang 1,2
Jingjing Sang 1
Jiang Yanyan 3 Yi Zheng 1 Jing Zhang 1 Xuesen Liu 2 Huafeng Qiu 1 Kaijian Zhao 1 Hongmei Sun 1 Yang Yang 2 Lei Yang 1,2*- 1 Huanghuai University, Zhumadian, China
- 2 Zhumadian Central Hospital, Zhumadian, China
- 3 First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China
Objective: To ascertain whether vascular complications and high lipoprotein (a) [ Lp(a)] concentrations are related in individuals with early-onset type 2 diabetes mellitus (T2DM).: This observational cross-sectional study included 591 individuals with early-onset T2DM who were divided into four groups based on Lp(a) values which was measured using immunoturbidimetry and presented as mg/dL: high, >50; intermediate, 30≤Lp(a)<50; low, 10≤Lp(a)<30; and very low, <10. The relationship between the risk of vascular complications and Lp(a) level was examined using a logistic regression model. Results: The median age of onset for individuals with early-onset T2DM (n=591) was 37 years, duration of diabetes was 12 years, and glycated hemoglobin (HbA1c) level was 8.8%. The median Lp(a) was 10.40 (4.80-21.80) mg/dL, and Lp(a) concentration did not correlate with age, sex, or glycemic control (P>0.05). Individuals in the low Lp(a) (OR=2.12, 95% CI 1.17-3.84, P<0.05), intermediate Lp(a) (OR=2.76, 95% CI 1.10-6.98, P<0.05) and high Lp(a) (OR=4.79, 95% CI 2.03-11.31, P<0.01) groups had an increased risk of coronary heart disease (CHD) compared with those in the very low Lp(a) group after adjustment. Nevertheless, among individuals with earlyonset T2DM, there was no correlation between Lp(a) concentration and the risk of cerebrovascular disease (CVL) and microvascular complications (P>0.05).In patients with early-onset T2DM, Lp(a) concentration was independently associated with CHD. Lp(a) testing is essential to determine who has a latent high risk of CHD among patients with early-onset T2DM.
Keywords: Lipoprotein (a), coronary heart disease, cerebrovascular disease, microvascular complications, Early-onset type 2 diabetes
Received: 18 May 2024; Accepted: 03 Apr 2025.
Copyright: © 2025 Zhang, Sang, Yanyan, Zheng, Zhang, Liu, Qiu, Zhao, Sun, Yang and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Lei Yang, Huanghuai University, Zhumadian, China
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