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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Cardiovascular Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1433106
This article is part of the Research Topic Endocrinology, Lipids, and Disease: Unraveling the Links View all 7 articles

Effect of thyroid stimulating hormone on the prognosis of coronary heart disease

Provisionally accepted
Ning Ding Ning Ding 1,2,3Rui Hua Rui Hua 1,2,3Hanqing Guo Hanqing Guo 4Yu Xu Yu Xu 2*Zuyi Yuan Zuyi Yuan 1,2,3*Yue Wu Yue Wu 1,2,3*Ting Li Ting Li 1,2,3*
  • 1 Key Laboratory of Molecular Cardiology, Shaanxi Province, Xi’an, Shaanxi, China, xi'an, China
  • 2 Department of Cardiovascular Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi'an, Shaanxi, China
  • 3 Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi’an Jiaotong University, Xi’an, Shaanxi, China
  • 4 Department of Gastroenterology, Xi’an Central Hospital, Xi’an Jiaotong University, Xi’an, Shaanxi, China., Xi‘an, China

The final, formatted version of the article will be published soon.

    Background: Clinical studies have shown that thyroid stimulating hormone (TSH) is associated with increased cardiovascular disease risk and mortality. Even within normal ranges, elevated TSH levels have an impact on the cardiovascular system and have been associated with cardiac dysfunction. The aim of our study was to evaluate the predictive value of admission fasting serum TSH levels in patients with coronary heart disease in relation to long-term major adverse cardiovascular events (MACE) and all-cause mortality.Method: A total of 3515 patients with coronary heart disease who met the inclusion criteria were divided into four groups according to the quantile of TSH levels: Group 1 (TSH, 0.34-1.02 mIU/L, n=878); Group 2 (TSH, 1.03-1.71 mIU/L, n=886); Group 3 (TSH, 1.72-2.84 mIU/L, n=880); and Group 4 (TSH, 2.86-5.50 mIU/L, n=873). MACE and all-cause mortality were also compared. TSH concentrations associated with the risk of MACE, all-cause mortality were assessed using continuous scales (restricted quartic splines) and Cox proportional hazards regression models.Results: A total of 3515 patients with coronary heart disease were eligible for analysis. At a median follow-up of 70 months, patients in group 2 had a lower incidence of MACE compared to the other three groups. All-cause mortality was lower in the 3rd group. Restricted quartic spline analysis also revealed that TSH concentrations were associated with heart failure risk.Conclusion: TSH levels have predictive value for adverse cardiovascular events and heart failure in patients with coronary heart disease.Key words: Thyroid stimulating hormone; Coronary-heart-disease; Major adverse cardiovascular events; Mortality; Prognosis

    Keywords: Thyroid stimulating hormone, Coronary-heart-disease, Major adverse cardiovascular events, Mortality, prognosis

    Received: 07 Jun 2024; Accepted: 23 Jan 2025.

    Copyright: © 2025 Ding, Hua, Guo, Xu, Yuan, Wu and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yu Xu, Department of Cardiovascular Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi'an, 710061, Shaanxi, China
    Zuyi Yuan, Department of Cardiovascular Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi'an, 710061, Shaanxi, China
    Yue Wu, Department of Cardiovascular Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi'an, 710061, Shaanxi, China
    Ting Li, Department of Cardiovascular Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi'an, 710061, Shaanxi, China

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