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ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Systems Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1427656
This article is part of the Research Topic Integrated Diagnostics and Biomarker Discovery in Endocrinology and Biomedical Sciences: Volume II View all articles
Causal relationship between plasma lipidome and rosacea: a Mendelian randomization analysis
Provisionally accepted- The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
Background: Rosacea is a common chronic inflammatory skin disease. Limited studies reported the association between plasma lipidome and rosacea.We employed a two-sample Mendelian randomization (MR) study to assess the causality between plasma lipidome and rosacea. Plasma lipidome association genome-wide association study (GWAS) data were collected. The inverse variance weighted (IVW) method was utilized as the principal method in our Mendelian randomization (MR) study, with additional using the MR-Egger, weighted median, simple mode, and weighted mode methods. The MR-Egger intercept test, Cochran's Q test, MR-Pleiotropy RESidual Sum and Outlier (MR-PRESSO) and leave-one-out analysis were conducted to identify heterogeneity and pleiotropy.Results: 179 lipid species were analyzed, among them, five lipid species were closely related to rosacea. Two species of sterol ester: sterol ester (27:1/22:6), sterol ester (27:1/15:0), two species of phosphatidylethanolamine: phosphatidylethanolamine (O-18:2_20:4), phosphatidylethanolamine (18:0_20:4), one species of sphingomyelin: sphingomyelin (d34:0) were causally associated with rosacea (P ＜ 0.05). All of them play protective roles in patients with rosacea. No heterogeneity or pleiotropy was observed.This study provided new evidence of the relationship between plasma lipidome and rosacea. Our MR suggested that five lipid species play protective roles in rosacea progression. These could be novel and effective ways to treat rosacea.
Keywords: Plasma lipidome, Rosacea, Mendelian randomization, causal inference, Protective
Received: 04 May 2024; Accepted: 07 Apr 2025.
Copyright: © 2025 Wang and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Zexin Zhu, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
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