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EDITORIAL article

Front. Endocrinol.
Sec. Reproduction
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1538412
This article is part of the Research Topic Benefits and Risks of Agonist Triggering Strategies View all 10 articles

Benefits and Risks of Agonist Triggering Strategies

Provisionally accepted
Jan Tesarik Jan Tesarik *
  • MARGen Clinic, Granada, Spain

The final, formatted version of the article will be published soon.

    Since many years, the GnRH analogues GnRHa and GnRHant are used alternatively for preventing 20 premature LH surge and ovulation in controlled ovarian stimulation protocols [1]. Recently, GnRHa 21 is also used in GnRHant-controlled cycles as an alternative to human chorionic gonadotropin (hCG) 22 to trigger final oocyte maturation and ovulation [2]. The use of these GnRH analogues simplifies the 23 ovarian stimulation protocol and reduces the risk of ovarian hyperstimulation syndrome [1,2]. After 24 initial warning voices, based on animal experiments and suggesting that GnRH and its analogues 25 may interfere with the early pregnancy through their action on the corpus luteum and the uterus [3], 26 these fears were not substantiated in clinical practice [1,2]. However, some doubts may still persist.

    Keywords: GnRH agonist, GnRH antagonist, Controlled ovarian stimulation, Embryo viability, 7 uterine receptivity, early pregnancy 8 9 10

    Received: 02 Dec 2024; Accepted: 13 Dec 2024.

    Copyright: © 2024 Tesarik. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jan Tesarik, MARGen Clinic, Granada, Spain

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.