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SYSTEMATIC REVIEW article

Front. Endocrinol.
Sec. Clinical Diabetes
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1514713

Serum osteocalcin levels are inversely associated with UACR in Chinese DKD patients: a meta-analysis of 20 clinical studies

Provisionally accepted
Xiaolan Hu Xiaolan Hu 1Xiyu Wang Xiyu Wang 1*Chen Cai Chen Cai 1*Jiachen Guo Jiachen Guo 1*Xin Qian Xin Qian 1*Jiangyi Yu Jiangyi Yu 2*Liji Huang Liji Huang 2*Shaofeng Xie Shaofeng Xie 1*
  • 1 Department of Endocrinology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China
  • 2 Department of Endocrinology, Affiliated Hospital to Nanjing University of Chinese Medicine, Nanjing, China

The final, formatted version of the article will be published soon.

    Objective: To systemically assess the relationship between serum osteocalcin levels and the progression of diabetic kidney disease (DKD) in the Chinese population. Methods: The PubMed, Web of Science, CNKI, Wanfang Database, VIP and Chinese Medical Journal full-text Database were searched. Two investigators independently reviewed the literature and extracted data based on predetermined inclusion and exclusion criteria. The Newcastle-Ottawa scale was used to assess the quality of the literature. The statistical analysis was performed using Stata16 software. Results: A total of 20 case-control studies encompassed 4565 cases, consisting of 643 healthy controls (CN), 1 649 individuals with simple diabetes mellitus (DM), 1 305 with microalbuminuria (MI), and 968 with macroalbuminuria (MA). The meta-analysis results indicated that the serum osteocalcin levels in MI group were significantly lower than that in CN group and DM group [SMD = -1.15, 95% CI (-1.46, -0.85), P < 0.01; and SMD = -0.53, 95% CI (-0.69, -0.37), P < 0.01, respectively], and lower in the MA group compared to the CN group [SMD = -1.28, 95% CI (-1.79, -0.76), P < 0.01]. In the MA group, the serum osteocalcin levels were considerably lower compared to that in DM group and MI group [SMD = -0.93, 95% CI (-1.28, -0.58), P < 0.01; and SMD = -0.41, 95% CI (-0.65, -0.17), P < 0.01, respectively]. Conclusion: The serum osteocalcin levels are typically reduced and show a negative correlation with the severity of proteinuria in Chinese patients with DKD. This indicates a decline in bone formation at early-stage in DKD patients, which worsens as the disease progresses. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/, identiļ¬er CRD42024580324.

    Keywords: Osteocalcin, Diabetic kidney disease, bone metabolism, case-control study, meta analysis

    Received: 21 Oct 2024; Accepted: 14 Nov 2024.

    Copyright: Ā© 2024 Hu, Wang, Cai, Guo, Qian, Yu, Huang and Xie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xiyu Wang, Department of Endocrinology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China
    Chen Cai, Department of Endocrinology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China
    Jiachen Guo, Department of Endocrinology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China
    Xin Qian, Department of Endocrinology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China
    Jiangyi Yu, Department of Endocrinology, Affiliated Hospital to Nanjing University of Chinese Medicine, Nanjing, China
    Liji Huang, Department of Endocrinology, Affiliated Hospital to Nanjing University of Chinese Medicine, Nanjing, China
    Shaofeng Xie, Department of Endocrinology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China

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