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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Clinical Diabetes
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1513543

The association between triglyceride-glucose index and neutrophil-lymphocyte ratio and all-cause mortality in the general US population: NHANES 2001-2018

Provisionally accepted
Yifei Wang Yifei Wang 1*Bingbing Chen Bingbing Chen 1Binxu Qiu Binxu Qiu 2Jinhai Yu Jinhai Yu 1*
  • 1 Department of Gastric, Colorectal and Anal Surgery, First Affiliated Hospital of Jilin University, Jilin University, Changchun, China
  • 2 Department of Breast Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China

The final, formatted version of the article will be published soon.

    The association between the triglyceride-glucose (TyG) index and mortality in the general population remains controversial, with inconsistent findings across studies.This study aims to investigate the relationship between the TyG index and mortality in the U.S. Additionally, it explores whether a new index, combining the TyG index with the neutrophil-to-lymphocyte ratio (NLR), improves the prediction of all-cause compared to the TyG index alone.TyG index were calculated based on participants' complete blood counts and fasting triglyceride and glucose levels. The TyG-NLR index was derived by multiplying the TyG index by the NLR. A weighted Cox proportional hazards model was used to evaluate the associations of the TyG and TyG-NLR indices with mortality risk in the general population. Restricted cubic splines (RCS) were applied to explore and visualize the dose-response relationships between the indices and mortality.This study included 15388 participants. During a median follow-up of 118 months, 2,333 participants died. After adjusting for potential confounders, no significant association was found between the TyG index and mortality. However, compared to the lowest quartile , participants in the highest quartile of the TyG-NLR index showed a significant association with all-cause mortality. Specifically, those in the highest quartile had a 63% higher risk of all-cause mortality .

    Keywords: TyG, NLR, Insulin Resistance, Mortality, NHANES

    Received: 18 Oct 2024; Accepted: 21 Nov 2024.

    Copyright: © 2024 Wang, Chen, Qiu and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yifei Wang, Department of Gastric, Colorectal and Anal Surgery, First Affiliated Hospital of Jilin University, Jilin University, Changchun, China
    Jinhai Yu, Department of Gastric, Colorectal and Anal Surgery, First Affiliated Hospital of Jilin University, Jilin University, Changchun, China

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