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REVIEW article

Front. Endocrinol.
Sec. Cellular Endocrinology
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1510712

Tools for Regulating Metabolic Diseases: Extracellular Vesicles from Adipose Macrophages

Provisionally accepted
Kecheng Lou Kecheng Lou 1*Liang Zhang Liang Zhang 2*Yunmeng Zhang Yunmeng Zhang 3Yuanjing Leng Yuanjing Leng 2*Yuqing Huang Yuqing Huang 2*Xinxin Liao Xinxin Liao 2*Xiaoliang Liu Xiaoliang Liu 2*Shangzhi Feng Shangzhi Feng 2*Guoqiang Feng Guoqiang Feng 4*
  • 1 Department of Urology, Lanxi People's Hospital, Jinhua,Zhejiang, China
  • 2 Dpartment of Urology, Jiujiang University Clinic College, Jiujiang, China
  • 3 Department of Anesthesiology, Jiujiang College Hospital, Jiangxi, China
  • 4 Department of Rehabilitation, Jiujiang College Hospital, Jiangxi, China

The final, formatted version of the article will be published soon.

    Metabolic diseases have gradually become one of the most significant global medical burdens. Diseases such as obesity, diabetes, and metabolic syndrome, along with their complications, are clinically categorized as metabolic diseases. Long-term oral medication significantly reduces patient compliance and quality of life. Therefore, alternative therapies that intervene at the cellular level or target the root causes of metabolic diseases might help change this predicament. Research has found that extracellular vesicles derived from adipose macrophages can effectively regulate metabolic diseases by influencing the disease's development. This regulation is likely related to the role of these extracellular vesicles as important mediators in modulating adipose tissue function and insulin sensitivity, and their involvement in the crosstalk between adipocytes and macrophages. This review aims to describe the regulation of metabolic diseases mediated by adipose macrophage-derived extracellular vesicles, with a focus on their involvement in adipocyte crosstalk, the regulation of metabolism-related autoimmunity, and their potential as therapeutic agents for metabolic diseases, providing new avenues for diagnosis and treatment.

    Keywords: Obesity, metabolic disease, Adipose tissue macrophage, extracellular vesicles, Nano-targeted therapy

    Received: 16 Oct 2024; Accepted: 20 Nov 2024.

    Copyright: © 2024 Lou, Zhang, Zhang, Leng, Huang, Liao, Liu, Feng and Feng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Kecheng Lou, Department of Urology, Lanxi People's Hospital, Jinhua,Zhejiang, China
    Liang Zhang, Dpartment of Urology, Jiujiang University Clinic College, Jiujiang, China
    Yuanjing Leng, Dpartment of Urology, Jiujiang University Clinic College, Jiujiang, China
    Yuqing Huang, Dpartment of Urology, Jiujiang University Clinic College, Jiujiang, China
    Xinxin Liao, Dpartment of Urology, Jiujiang University Clinic College, Jiujiang, China
    Xiaoliang Liu, Dpartment of Urology, Jiujiang University Clinic College, Jiujiang, China
    Shangzhi Feng, Dpartment of Urology, Jiujiang University Clinic College, Jiujiang, China
    Guoqiang Feng, Department of Rehabilitation, Jiujiang College Hospital, Jiangxi, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.