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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Thyroid Endocrinology
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1509501
This article is part of the Research Topic Hormones and Aging related diseases View all 8 articles

Association of T3/T4 ratio with inflammatory indicators and all-cause mortality in stroke survivors

Provisionally accepted
Zhang Sheng Zhang Sheng zhou zhong Su zhou zhong Su *qiang Xian Wen qiang Xian Wen *
  • Huzhou Central Hospital, Huzhou, China

The final, formatted version of the article will be published soon.

    Abnormal thyroid hormone levels may occur in critical illness, which may have an interactive relationship with inflammatory reaction. At present, the relationship between triiodothyronine (T3)/ thyroxine (T4) ratio and inflammatory indicators and all-cause mortality of stroke survivors is still unclear. According to the inclusion and exclusion criteria, a total of 267 people were included in the study, with a mortality rate of 49.06%. The Log-Rank test and K-M survival curve showed that there were statistical differences among the Q1, Q2, and Q3 groups of the T3/T4 ratio . Pearson correlation analysis showed that the T3/T4 ratio had a weak correlation with NPAR (r = -0.31, p＜0.001). Cox univariate analysis showed that age, marital status, race, cancer, T3/T4 ratio, NPAR and all-cause mortality were related. Multivariate regression analysis showed that age ≥ 60 years, race of non-Hispanic black, low T3/T4 ratio and high NPAR were independent risk factors for all-cause mortality. Subgroup analysis showed that T3/T4 ratio is more likely to affect the survival of stroke survivors with BMI 18.5~28. Mediation effect analysis showed that there was a mediation effect between T3/T4 ratio, NPAR and survival time. Conclusions: T3/T4 ratio is an independent risk factor for all-cause mortality in stroke survivors, especially in the people with BMI 18.5~28. T3/T4 ratio may mediate the survival time through NPAR level. Therefore, monitoring thyroid function is beneficial to the management of stroke survivors.

    Keywords: ：NHANES, Stroke, T3/T4 ratio, NPAR, mediation effect, Forest plot

    Received: 11 Oct 2024; Accepted: 16 Dec 2024.

    Copyright: © 2024 Sheng, Su and Wen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    zhou zhong Su, Huzhou Central Hospital, Huzhou, China
    qiang Xian Wen, Huzhou Central Hospital, Huzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.