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CASE REPORT article

Front. Endocrinol.
Sec. Neuroendocrine Science
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1509060

Case Report: Persistent Syndrome of Inappropriate Antidiuresis After Traumatic Brain Injury: Spontaneous Resolution and Impact on RAAS and Bone Metabolism Over Five Years

Provisionally accepted
Yaoxia Liu Yaoxia Liu 1Jiao Tang Jiao Tang 2,3,4Mingwei Zhou Mingwei Zhou 5*HaoTian Huang HaoTian Huang 5Tao Wang Tao Wang 2,3*Min Zhang Min Zhang 1*
  • 1 Department of Geriatric Endocrinology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, ChengDu, China
  • 2 Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan Province, China
  • 3 Ministry of Education, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), ChengDu, China
  • 4 The First People's Hospital of Longquanyi District, ChengDu, China
  • 5 School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China

The final, formatted version of the article will be published soon.

    The syndrome of Inappropriate Antidiuresis (SIAD) is a well-known cause of hyponatremia and can be associated with various etiologies, including traumatic brain injury (TBI). Most cases of SIAD following TBI exhibit a pattern in which hyponatremia develops several days to weeks after the trauma and resolves within a few weeks. Here, we present a rare case of persistent SIAD caused by TBI that resolved spontaneously after five years. The patient experienced prolonged hyponatremia for several years and was ultimately diagnosed with post-traumatic SIAD after excluding other potential causes. Notably, the patient exhibited an unusual sensitivity to tolvaptan, accompanied by decreased renin levels and increased bone turnover markers. The condition resolved spontaneously after five years, with renin, aldosterone, and bone turnover markers returning to normal upon re-evaluation.

    Keywords: SiaD, Hyponatremia, traumatic brain injury ( TBI ), Tolvaptan, Renin-angiotensin-aldosterone system (RAAS), bone metabolism

    Received: 10 Oct 2024; Accepted: 30 Dec 2024.

    Copyright: © 2024 Liu, Tang, Zhou, Huang, Wang and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Mingwei Zhou, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 611731, Sichuan Province, China
    Tao Wang, Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China
    Min Zhang, Department of Geriatric Endocrinology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, ChengDu, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.