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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Pediatric Endocrinology
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1507643

The correlations of serum uric acid with lean mass, fat mass and grip strength in adolescents aged 12-19 years

Provisionally accepted
Feng Xu Feng Xu 1Jianjun Shen Jianjun Shen 2Zhongxin Zhu Zhongxin Zhu 1,3*
  • 1 The First people's Hospital of Xiaoshan District, Hangzhou, Jiangsu Province, China
  • 2 Community Health Service Center of Guali, Hangzhou, China
  • 3 Clinical Research Center, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

The final, formatted version of the article will be published soon.

    Background: Serum uric acid (sUA) has emerged as an intriguing modulator of body composition and physical function, yet its complex associations with musculoskeletal parameters during the critical period of adolescence remain incompletely characterized. To address this knowledge gap, we sought to elucidate the relationships between sUA and key indicators of body composition and musculoskeletal health in adolescents aged 12-19 years, specifically examining appendicular lean mass index (ALMI), appendicular fat mass index (AFMI), and combined grip strength.In this cross-sectional study, we analysed data from 2,003 adolescents participating in the National Health and Nutrition Examination Survey (NHANES) 2011-2014. We examined the relationships between sUA and ALMI, AFMI, and combined grip strength using multivariate linear regression models. Subgroup analyses were conducted to explore effect modifications by age, sex, and race/ethnicity. Results: Higher sUA levels were positively associated with ALMI and grip strength, and inversely associated with AFMI after adjusting for potential confounders. These associations exhibited distinct patterns across age, sex, and race subgroups, with the most pronounced effects observed among boys aged 12-15 years and in non-Hispanic White and Black populations.Our findings demonstrated significant associations between sUA levels and various parameters of musculoskeletal health and body composition, suggesting that sUA may serve as a potential biomarker for monitoring physical development and maturation during adolescence.

    Keywords: Uric Acid, Body Composition, Muscle Strength, Adolescent, NHANES

    Received: 08 Oct 2024; Accepted: 19 Dec 2024.

    Copyright: © 2024 Xu, Shen and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Zhongxin Zhu, Clinical Research Center, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.