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CASE REPORT article

Front. Endocrinol.
Sec. Pediatric Endocrinology
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1505382

Looking for relationship between type 1 diabetes and chronic recurrent osteomyelitis: short literature review and case presentation

Provisionally accepted
Ingrida Stankute Ingrida Stankute 1,2,3*Ausra Snipaitiene Ausra Snipaitiene 4Laura Radzeviciute Laura Radzeviciute 2Rimante Dobrovolskiene Rimante Dobrovolskiene 2
  • 1 Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania
  • 2 Lithuanian University of Health Sciences, Kaunas, Kaunas, Lithuania
  • 3 Institute of Endocrinology, Lithuanian University of Health Sciences, Kaunas, Lithuania
  • 4 Department of Pediatrics, Lithuanian University of Health Sciences, Kaunas, Lithuania

The final, formatted version of the article will be published soon.

    Background: Childhood autoimmune disorders involve the immune system attacking its own tissues, leading to varied symptoms, while autoinflammatory disorders result from innate immune system dysregulation, both requiring extensive diagnosis and multidisciplinary management due to their complexity.We present a unique clinical case of a teenager with a combination of autoimmune and autoinflammatory disorders. The initial manifestation of hip pain, coupled with progressive symptoms over several years and findings in multiple magnetic resonance imaging (MRI) scans, culminated in the diagnosis of chronic recurrent multifocal osteomyelitis (CRMO). Subsequently, the patient was diagnosed with type 1 diabetes (T1D), celiac disease, and juvenile idiopathic arthritis.The therapeutic course proved challenging, marked by unsuccessful attempts with nonsteroidal anti-inflammatory drugs (NSAIDs), and biphosphonates. However, a stable clinical status was ultimately achieved upon the introduction of methotrexate, concomitant with insulin therapy for diabetes and the implementation of a gluten-free diet for celiac disease.2 Conclusions: Our case showed that the combination of autoimmune and autoinflammatory diseases, brought not only a challenging diagnostic process, but also complicated treatment.

    Keywords: chronic recurrent multifocal osteomyelitis, type 1 diabetes, Celiac Disease, Autoimmunity, Autoinflammation

    Received: 02 Oct 2024; Accepted: 29 Nov 2024.

    Copyright: © 2024 Stankute, Snipaitiene, Radzeviciute and Dobrovolskiene. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Ingrida Stankute, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.