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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Diabetes: Molecular Mechanisms
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1505082
This article is part of the Research Topic Understanding and Managing Diabetic Neuropathy: Current Perspectives and Future Directions View all 6 articles

Association of circulating adiponectin and leptin levels with the risk of diabetic peripheral neuropathy

Provisionally accepted
Zongcun Chen Zongcun Chen 1Shasha Fu Shasha Fu 2*Shuchang Lai Shuchang Lai 1*Maoxiong Fu Maoxiong Fu 1*Guankui Du Guankui Du 3*
  • 1 Second Affiliated Hospital of Hainan Medical University, Haikou, China
  • 2 Haikou Affiliated Hospital of Central South University Xiangya School of Medicine, Haikou, China
  • 3 Hainan Medical University, Haikou, Hainan Province, China

The final, formatted version of the article will be published soon.

    Background: Adipokines have been implicated in the pathogenesis of type 2 diabetes mellitus (T2DM) and related complications due to their roles in metabolic regulation and inflammation. However, the relationship between these adipokines and diabetic peripheral neuropathy (DPN) remains unclear.Methods: A case-control study was performed with 198 patients with DPN and 205 T2DM patients without DPN from the Endocrinology Department at the Second Affiliated Hospital of Hainan Medical University. Circulating adiponectin and leptin levels were quantified via enzyme-linked immunosorbent assays. Logistic regression models, adjusting for age, sex, BMI, smoking status, and diabetes duration, were applied to evaluate the associations between adiponectin and leptin levels and DPN risk.Results: DPN patients exhibited lower adiponectin (P=0.001) and higher leptin (P=0.007) levels than diabetic controls. Confounders-adjusted analyses revealed that higher adiponectin levels correlated with reduced DPN risk (OR, tertile 3 vs. tertile 1: 0.52; 95% CI: 0.30-0.90), whereas elevated leptin levels were linked to increased DPN risk (OR, tertile 3 vs. tertile 1: 1.91; 95% CI: 1.10-3.32). Stratified analyses confirmed consistent findings across subgroups without statistically significant interactions.Conclusions: Circulating adiponectin and leptin levels correlate with DPN risk in diabetic patients, suggesting their potential as biomarkers for high-risk DPN identification and guiding targeted prevention and management.

    Keywords: Diabetic peripheral neuropathy, Adiponectin, Leptin, Association, case-control study

    Received: 02 Oct 2024; Accepted: 21 Nov 2024.

    Copyright: © 2024 Chen, Fu, Lai, Fu and Du. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Shasha Fu, Haikou Affiliated Hospital of Central South University Xiangya School of Medicine, Haikou, China
    Shuchang Lai, Second Affiliated Hospital of Hainan Medical University, Haikou, China
    Maoxiong Fu, Second Affiliated Hospital of Hainan Medical University, Haikou, China
    Guankui Du, Hainan Medical University, Haikou, 571199, Hainan Province, China

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