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REVIEW article

Front. Endocrinol.
Sec. Cardiovascular Endocrinology
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1503704
This article is part of the Research Topic Molecular Biomarkers of Cardiometabolic Disease - Volume II View all articles

Research Progress on the Relationship Between Free Fatty Acid Profile and Type 2 Diabetes Complicated by Coronary Heart Disease

Provisionally accepted
Xiuyan Liu Xiuyan Liu Na Wu Na Wu *
  • Sheng Jing Hospital Affiliated, China Medical University, Shenyang, China

The final, formatted version of the article will be published soon.

    Patients with type 2 diabetes mellitus (T2DM) have a 2 to 3 times higher risk of cardiovascular disease compared to non-diabetic individuals, and cardiovascular disease has consistently been a leading cause of death among diabetic patients. Therefore, preventing cardiovascular disease in diabetic patients remains a significant challenge. In addition to classic indicators such as cholesterol and lipoproteins, previous studies have demonstrated that plasma level of free fatty acid (FFA) is closely related to the occurrence of atherosclerosis, particularly in T2DM patients. In recent 2 years, with further research and advancements in testing technologies, the FFA profile has garnered widespread attention. The FFA profile includes many different types of FFAs, and changes in the plasma FFA profile and concentrations in T2DM patients may lead to the development of insulin resistance, causing damage to vascular endothelial cells and promoting the occurrence and progression of atherosclerosis. Furthermore, some FFAs have shown potential in predicting cardiovascular complications in T2DM and are associated with the severity of these complications. Here, we aim to review the changes in the FFA profile in T2DM and discuss the relationship between the FFA profile and the occurrence of vascular complications in T2DM.

    Keywords: Free fatty acid profile, polyunsaturated fatty acids, coronary heart disease, type 2 diabetes, Atherosclerosis

    Received: 29 Sep 2024; Accepted: 14 Nov 2024.

    Copyright: © 2024 Liu and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Na Wu, Sheng Jing Hospital Affiliated, China Medical University, Shenyang, China

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