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ORIGINAL RESEARCH article

Front. Endocrinol.
Sec. Endocrinology of Aging
Volume 15 - 2024 | doi: 10.3389/fendo.2024.1500712

Determining the status of small dense low-density lipoprotein cholesterol level in women undergoing menopausal transition

Provisionally accepted
Qingfang He Qingfang He *Yujia Fang Yujia Fang Lixin Wang Lixin Wang *Mingbin Liang Mingbin Liang *Xiangyu Chen Xiangyu Chen Ruying Hu Ruying Hu *Jieming Zhong Jieming Zhong *
  • Zhejiang Provincial Center for Disease Control and Prevention, Hang zhou, China

The final, formatted version of the article will be published soon.

    Objective: Research on small dense low-density lipoprotein cholesterol (sdLDL-C) and menopausal status remains scarce. Our aim is to evaluate the relationship between serum sdLDL-C level and different menopausal status in a Chinese women population. Methods: In 2022 a cross-sectional study was conducted including electronic standardized questionnaire surveys, anthropometric measurements and biological specimen examinations based on communities. Permanent resident adults aged 30-69 years who lived in two communities in Zhejiang Province and participated in a community health examination from May 26th to September 17th were recruited. According to their menopausal status, the eligible women subjects were divided into premenopause, perimenopause, and postmenopause. Logistic regression model by SAS software was used to explore the association with sdLDL-C level and different menopausal status. Results: A total of 2062 women subjects were included with a median age of 57 (51, 63) years. There were 451 (21.9%) premenopause, 87 (4.2%) perimenopause and 1524 (73.9%) postmenopause women. The median sdLDL-C level was 0.937 (0.685, 1.209) mmol/L and sdLDL-C levels showed a gradually and significantly upward trend in premenopause, perimenopause and postmenopause women, and peaked in the postmenopause women. Logistic regression analysis showed that after controlling the confounding factors, compared with the premenopause, postmenopause was significantly associated with the increased sdLDL-C concentration(OR=1.514, 95% CI:1.025-2.238), while no significant association was observed either between serum sdLDL-C and the perimenopause (compared with the premenopause), or between serum sdLDL-C and the postmenopause (compared with the perimenopause). Conclusions: Elevated sdLDL-C level was significantly associated with the postmenopause and independent of chronological aging. The study supports that sdLDL-C is a promising risk biomarker for menopausal transition. Future studies should consider a broader population and a more rigorous and thorough study design to validate these findings.

    Keywords: Small dense low-density lipoprotein cholesterol, Premenopause, Perimenopause, Postmenopause, Menopausal transition

    Received: 23 Sep 2024; Accepted: 19 Dec 2024.

    Copyright: © 2024 He, Fang, Wang, Liang, Chen, Hu and Zhong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Qingfang He, Zhejiang Provincial Center for Disease Control and Prevention, Hang zhou, China
    Lixin Wang, Zhejiang Provincial Center for Disease Control and Prevention, Hang zhou, China
    Mingbin Liang, Zhejiang Provincial Center for Disease Control and Prevention, Hang zhou, China
    Ruying Hu, Zhejiang Provincial Center for Disease Control and Prevention, Hang zhou, China
    Jieming Zhong, Zhejiang Provincial Center for Disease Control and Prevention, Hang zhou, China

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